논문 상세보기
pp.165-172
목적: 인공누액은 하이드로젤 및 하드 콘택트렌즈 사용자의 불편함을 해소하기 위하여 사용된다. 또한 HPMC(Hydroxypropyl methylcellulos)는 인공 누액에 사용되는 일반적인 습윤성 재료 중 하나이다. 본 연구는 HPMC를 포함한 인공누액이 하이드로젤 콘택트렌즈에 미치는 영향을 다양한 조건에서 분석하였다. 방법: 하이드로젤 콘택트렌즈 제조를 위해 NVP(n-vinyl-2-pyrrolidone)와 MMA(methyl methacrylate)를 가교제인 EGDMA(Ethylene glycol dimethacrylate)를 사용하여 HEMA(2-hydroxyethyl methacrylate)와 공중합하였으며, 개시제로는 AIBN(azobisiobutyonitrile)을 사용하였다. 또한 제조된 렌즈의 물리적 특성을 평가하기 위해 함수율, 굴절률, 접촉각, 분광투과율 등을 측정하였다. 결과: 제조된 콘택트렌즈의 기본 물성을 측정한 결과, 함수율 27.64∼48.33%, 굴절률 1.424∼1.453, 분광투과율의 경우, 82.0∼92.0%의 범위로 나타났으며 접촉각은 39.47∼51.52°로 나타났다. 또한 제조된 콘택트렌즈를 인공누액에 침지시킨 후 측정한 물리적 특성은 함수율 25.86∼48.26%, 굴절률 1.424∼1.456, 광투과율 76.0∼92.0%의 범위로 나타났으며 접촉각의 경우는 26.55∼49.63°의 값으로 측정되었다. 침지시간에 따른 물성 변화를 분석한 결과, 굴절률의 증가, 함수율의 감소, 광투과율 및 접촉각의 감소를 나타내었다. 결론: HPMC를 포함한 인공누액은 친수성 하이드로젤 콘택트렌즈의 함수율, 굴절률, 접촉각 그리고 광투과율에 영향을 주는 것으로 나타났다.
Purpose: Artificial tear is considered as an important functional material to solve the irritation of contact lens wearers. Hydroxypropyl methylcellulose is one of the general materials used for artificial tear. In this study, the impacts of artificial tear including hydroxypropyl methylcellulose on the hydrogel contact lens were analyzed in various conditions. Methods: The cross-linking agent, EGDMA(ethylene glycol dimethacrylate) and HEMA (2-hydroxyethyl methacrylate) were determined to be used as the basic combination to produce a soft hydrogel contact lens. Also, NVP (n-vinyl-2-pyrrolidone) and MMA (methyl methacrylate) were added to this combination for classification of water content. The physical properties such as water content, refractive index, spectral transmittance and contact angle of produced contact lens were measured. Results: Measurement of the physical properties of the copolymerized polymer showed that water content, refractive index, visible ray transmittance and contact angle were in the range of 27.64∼48.33%, 1.424∼1.453, 82.0∼92.0% and 39.47∼51.52°, respectively. In addition, for the measured physical property after soaking into artificial tear, the water content, refractive index and contact angle were in the range of 25.86∼48.26%, 1.424∼1.456, 76.0∼92.0% and 26.55∼49.63°, respectively. The changes of the physical property depending on hydration time showed the increase of refractive index, decrease of water content, visible ray transmittance and contact angle. Conclusions: Artificial tear including hydroxypropyl methylcellulose which is used as wetting material, influenced water content, refractive index, contact angle and spectral transmittance of a hydrogel contact lenses.
