The purpose of this study was to evaluate the inhibitory effect of commercial Makgeolli on tumor growth in human gastric adenocarcinoma cells (AGS) in a xenograft cancer model, transplanted with AGS cells. Commercial Makgeolli was first dealcoholized by evaporation and used as the test sample. We detected a significant increase in the volume and weight of tumor in nude mice (induction) that were transplanted with AGS cells. Administration of 100 mg/kg·day group (ML), and 500 mg/kg·day group (MH) dealcoholized commercial Makgeolli significantly decreased tumor growth. In this study, 5-FU 18 mg/kg·day was used as a positive control for tumor growth inhibition. Additionally, determination of the body weight of both the groups revealed no side effects after the administration of dealcoholized commercial Makgeolli. Using the cell culture system, we also evaluated the effect of dealcoholized commercial Makgeolli on caspase-3/7 activity in the AGS cells. Treatment with dealcoholized commercial Makgeolli increased the activation of caspase-3/7 and the apoptotic markers in AGS cells in a dose-dependent manner. Therefore, dealcoholized commercial Makgeolli can be used for cancer prevention.

• 신은주(한국식품연구원, 과학기술연합대학원) | Eun-Ju Shin
• 김재호(한국식품연구원) | JaeHo Kim
• 성기승(한국식품연구원) | Ki-Seung Seong
• 염성관(서울장수 주식회사) | Sung-Kwan Yum
• 황진택(한국식품연구원, 과학기술연합대학원) | Jin-Taek Hwang Corresponding author