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Coexistence of Chronic Myelogenous Leukemia and Diffuse Large B-Cell Lymphoma

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The Medical Journal of Chosun University (조선대학교 의대논문집)
조선대학교 의학연구원 (Institute of Medical Science, Chosun University)
초록

Diagnosis of chronic myelogenous leukemia (CML) and non-Hodgkins lymphoma (NHL) have rarely been made simultaneously in the same patient. We report a rare case of a patient with CML-chronic phase who developed a concurrent Philadelphia (Ph)-negative diffuse large B-cell lymphoma. At the time of diagnosis, cytogenetic analysis of peripheral blood and bone marrow cells revealed the Ph-chromosome translocation in all examined metaphases. A lymph node biopsy showed features of diffuse large B-cell lymphoma, and fluorescence in situ hybridization (FISH) of lymph node tissue for BCR-ABL was negative. The patient was treated with R-CHOP (rituximab, cyclophosphamide, vincristine, adriamycin and prednisone) and imatinib mesylate.

목차
Introduction
Case Description
Discussion
Acknowledgement
References
저자
  • Hee-Jeong Lee(Department of Internal Medicine, Chosun University Hospital)
  • Choon-Hae Chung(Department of Internal Medicine, Chosun University Hospital)
  • Chi-Young Park(Department of Internal Medicine, Chosun University Hospital) Corresponding author