Background: Root diseases caused by Cylindrocarpon destructans and Fusarium solani decrease the yield and quality of ginseng. Cylindrocarpon root rot is a major disease caused by replant failure in ginseng fields. Methods and Results: Solarization of infested greenhouse soil was carried out during the summer season after applying green manure (Sudan grass) and Calcium Cyanamide (CC) on the soil. Mycelium and conidia of C. destructans died at 40℃ after 15 h, but they did not die at 35℃ after 15 h. They also died after keeping the soil at 40℃ for 2 h daily for 9 days, and at 45℃ for 8 days, but they did not die at 38℃ for 9 days. Maximum soil temperature was 55.4℃ at 5 ㎝ depth, 48.7℃ at 10 ㎝, 44.7℃ at 15 ㎝, 42.5℃ at 20 ㎝, and 31.9℃ at 30 ㎝ by incorporating green manure into the soil and using solarization. Solarization using green manure mixed with CC was the most effective in decreasing soil-borne pathogens of 2-year-old ginseng. However, the addition of CC decreased the root weight due to the increase in EC and NO3-N. Conclusions: Soil disinfection using green manure and solarization in a greenhouse environment was effective in inhibiting root rot, however, it did not completely kill the soil-borne pathogens.