This study was performed to investigate the correlation between the primary squamous cell carcinoma in oral cavity (POSCC) and paired metastatic oral squamous cell carcinoma in cervical lymph node (MOSCC) via immunohistochemical staining with Ki-67 and p53. The subjects included ten patients (20 specimens) who were diagnosed with OSCC with metastatic lymph nodes from 2010 to 2015 and surgically treated involving neck dissection in Kyungpook National University Hospital. Twenty specimens were stained immunohistochemically with Ki-67 and p53. The degrees of immunostaining by Ki-67 and p53 was evaluated as 0 (no positive cells), weak (1~25% positive cells), moderate (26-50% positive cells) and strong (>50% positive cells). Despite the strong tendency, there was no statistically significant result between expressions of Ki-67 and p53 in POSCC or MOSCC. We found that high expression of Ki-67 was significantly correlated with poor degree of differentiation. Our results suggest that expression of Ki-67 may be a predictable factor for degree of differentiation of POSCC and MOSCC.

Ⅰ. INTRODUCTION
 Ⅱ. MATERIALS and METHODS
  Patients and tissue sample
  Immunohistochemistry
  Statistical analysis
 1. Clinicopathological characteristics
 2. Immunohistochemical staining
 Ⅲ. RESULTS
 IV. DISCUSSION
 V. REFERENCES

• So-Young Choi(Department of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) | 최소영
• Jin-Wook Kim(Department of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) | 김진욱
• Young-In Park(Department of Oral & Maxillofacial Surgery, School of Dentistry, Kyungpook National University) | 박영인
• Sung-Min Kang(Department of Microbiology and Immunology, School of Dentistry, Kyungpook National University) | 강성민
• Su-Hyung Hong(Department of Microbiology and Immunology, School of Dentistry, Kyungpook National University) | 홍수형 Corresponding Author