This study was performed to investigate the correlation between the primary squamous cell carcinoma in oral cavity (POSCC) and paired metastatic oral squamous cell carcinoma in cervical lymph node (MOSCC) via immunohistochemical staining with Ki-67 and p53. The subjects included ten patients (20 specimens) who were diagnosed with OSCC with metastatic lymph nodes from 2010 to 2015 and surgically treated involving neck dissection in Kyungpook National University Hospital. Twenty specimens were stained immunohistochemically with Ki-67 and p53. The degrees of immunostaining by Ki-67 and p53 was evaluated as 0 (no positive cells), weak (1~25% positive cells), moderate (26-50% positive cells) and strong (>50% positive cells). Despite the strong tendency, there was no statistically significant result between expressions of Ki-67 and p53 in POSCC or MOSCC. We found that high expression of Ki-67 was significantly correlated with poor degree of differentiation. Our results suggest that expression of Ki-67 may be a predictable factor for degree of differentiation of POSCC and MOSCC.
Dermoid cysts represent approximately 34% of developmental cysts in the head and neck region, and they occur mostly at the midline of the floor of the mouth. However, dermoid cysts may also migrate laterally by expansion. The lesion is usually slow growing and painless, presenting as a doughy or rubbery mass that frequently retains pitting after application of pressure. The differential diagnosis for dermoid cysts includes infections, tumors, mucous extravasation phenomena and abnormalities arising during embryonic development.
In this report, we present three cases of unusual oral dermoid cysts. The first case developed on the left floor of the mouth, the second case was in the left submandibular area, and the third case was in the sublingual and submental space. All lesions were removed by the intraoral approach. Histopathologic examination revealed a dermoid cyst. The cysts were lined by orthokeratinized stratified squamous epithelium, with a prominent granular cell layer. The cyst walls were composed of fibrous connective tissue that contained sebaceous glands, sweat glands, and hair follicles.
Osteochondroma is one of the most common benign tumors of the bone. Although osteochondroma is rarely seen in the facial region, it was reported that the cases occured in the mandibular region, especially around the condyle. Patients complain about malocclusion, temporomandibular disorders and facial asymmetry. The treatments of these cases include total condylectomy or local resection of the lesion.
A 48-year-old man visited our hospital. His chief complaints were pain in the left temporomandibular joint (TMJ) and deviation of mandible during mouth opening. Panoramic radiograph showed an enlarged left condyle. A bony proliferation with benign sign was also observed in the computed tomography.
Surgical treatment was done by removing the bony mass. Histologically, biopsy result was an osteochondroma. After surgery, there was reduced pain and normal mouth opening. Deviation of the mandible was also observed.
We report a case of osteochondroma on the mandibular condyle and a review of literature about the surgical treatment.
The purpose of this case report was describe the management of impacted and dilacerated mandibular secondary primary molar with cystic formation associated with odontoma. A four-year-old male patient was presented unerupted mandibular left secondary primary molar. Radiographic examination revealed radiopaque mass on left posterior mandible, an impacted and dilacerated mandibular secondary primary molar, and a well defined osteolytic lesion surrounding crown of the impacted tooth. Under local anesthesia, the patient was treated by surgical removal of the odontoma and marsupialization of the cystic cavity. After 14 months, the secondary primary molar had erupted and there was no recurrence.
Extramedullary plasmacytomas (EMPs) are rare soft tissue malignant neoplasms composed of plasma cells. They are sometimes found in soft tissues. The majority of primary EMPs occur in the head and neck region, especially in the upper respiratory tract and oral cavity. We present a case of a 52-year-old female with an EMP. The patient’s initial chief complaint was swelling of the soft palate. An excisional biopsy was performed under general anesthesia. Final pathologic diagnosis was EMP of the soft palate with partial involvement of the resection margin. In order to exclude the possibility of multiple myeloma, a bone marrow exam with chromosomal study was completed. The patient was also referred to the Department of Radiation Oncology for postoperative radiation therapy (PORT); however, the patient refused to undergo PORT. The patient is currently under close observation for signs and symptoms of recurrence or metastases through regular follow-up visits and imaging studies.