간행물
대한구강악안면병리학회지 KCI 등재 The Korean Journal of Oral and Maxillofacial Pathology
- 발행기관 대한구강악안면병리학회
- 자료유형 학술지
- 간기 격월간
- ISSN 1225-1577 (Print)2384-0900 (Online)
- 수록기간 1977 ~ 2025
- 주제분류 의약학 > 치의학 의약학 분류의 다른 간행물
- 십진분류KDC 515DDC 610
권호리스트/논문검색
제48권 제6호 (2024년 12월) 4건
1.
2024.12
구독 인증기관 무료, 개인회원 유료
Burning mouth syndrome is a rare disorder of a complex nature that significantly impairs the life quality of those affected. Its clinical features are characterized by oral burning sensation as well as xerostomia, dysgeusia, and halitosis. While various etiological factors have been proposed over the last few decades, recent studies have focused on understanding its pathophysiology as a neuropathic disorder that involves both peripheral and central neuropathy. In addition, other explanations of BMS pathology have also been proposed, including hormonal disturbances during and after menopause, immunological challenges, and psychological distress. Despite these research efforts, the etiology of BMS remains elusive, awaiting further investigations. The scope of this review includes the current understanding of BMS pathology and animal models developed for deciphering molecular mechanisms underlying the development and progression of BMS. The overview of recent research efforts and our knowledge of BMS pathology will provide an opportunity to evaluate the status of our understanding of BMS and its future perspective in improving the life quality of those affected by this rather intractable disorder.
4,000원
2.
2024.12
구독 인증기관 무료, 개인회원 유료
Natural products have recently emerged as promising candidates for anticancer therapeutics. However, research on their use as adjuvants to existing chemotherapeutic agents in the treatment of oral squamous cell carcinoma (OSCC) remains limited. This study investigated the potential of METO, a methanol extract derived from Thuja orientalis, to induce apoptosis and its underlying mechanisms in the OSCC cell line HSC4. The results demonstrated that METO induces apoptosis in HSC4 cells, which is likely mediated through the activation of the ERK and JNK pathways, both of which were observed to be activated in METO-treated cells. Additionally, METO-induced apoptosis appears to involve signaling pathways associated with SOCS3 and p53. These findings highlight that METO exhibits strong anticancer activity in OSCC cells and suggest its potential as a promising chemotherapeutic agent for OSCC treatment.
4,000원
3.
2024.12
구독 인증기관 무료, 개인회원 유료
A 34-year-old male patient presented with a gradual facial asymmetry and occasional discomfort in the right temporomandibular joint (TMJ). Initial evaluation, including panoramic radiography, suggested facial asymmetry secondary to condylar elongation. However, computerized tomography and magnetic resonance imaging demonstrated the existence of a condylar mass and multiple calcified lesions within the right TMJ. The patient did not recognize any occlusal changes, but it was suspected that the occlusion had changed based on the cast analysis. The patient underwent a condylectomy and mass excision, which confirmed the diagnosis of osteochondroma with concurrent synovial chondromatosis. Approximately three weeks of postoperative physical therapy were required to achieve stable occlusion. This case is notable for two reasons. First, the simultaneous occurrence of osteochondroma and synovial chondromatosis is extremely rare. Second, the gradual occlusal changes associated with TMJ lesions can go undetected, increasing the chance of misdiagnosis.
4,000원
4.
2024.12
구독 인증기관 무료, 개인회원 유료
Acneiform eruptions are skin diseases that mimic acne vulgaris but lacking typical follicular blockage features. Acne vulgaris and some granulomatous variants of acneiform eruptions can involve Cutibacterium acnes, an anaerobic opportunistic bacterium; however, some cases remain resistant to standard antibiotics treatments. We report a 56-year-old male with facial acneiform granulomas unresponsive to long-term antibiotic and steroid treatments. The patient had no history of additional medications or other diseases, except symptomatic apical periodontitis in a molar toot. Both facial skin and dental lesions shared a key finding, intracellular infection of C. acnes within macrophages, despite differing histopathological features. The facial acneiform eruptions did not respond to initial minocycline treatment. However, following extraction of the infected tooth, the facial granuloma responded to the antibiotics and resolved without complications. PCR analysis confirmed C. acnes DNA in both the dental and skin biopsies. This case indicates the C. acnes-associated oral-skin-microbiome axis although a direct causal link between the distinct lesions could not be fully established. Odontogenic infection may act as reservoirs, impairing efficacy of antibiotic treatment. We recommend dental evaluation for case of facial acneiform granulomas that do not respond to antibiotics alone.
4,000원
