Agarum clathratum (A. clathratum) is a marine brown algal species that belongs to the Costariaceae family and has antioxidant and anti-microbial properties. However, the anti-inflammatory effects of A. clathratum and the molecular mechanisms involved have not been determined so far. This study aimed to investigate the anti-inflammatory effects of A. clathratum extracts in THP-1 macrophages stimulated by lipopolysaccharide (LPS) derived from Porphyromonas gingivalis. The THP-1 cells were differentiated with 12-O-tetradecanoylphorbol-13-acetate and treated with A. clathratum before LPS stimulation. Cell viability was assessed using the trypan blue exclusion assay. The expression of pro-inflammatory response-associated molecules was evaluated by quantitative real-time polymerase chain reaction and Western blot analysis. A. clathratum treatment inhibited the expression of interleukin-1β in LPS-stimulated THP-1 macrophages without causing any cytotoxicity. The anti-inflammatory effect of A. clathratum resulted in a significant repression of the JNK/c-Jun signaling axis, a key regulator in inflammation responses. This study highlights the possible role of A. clathratum in the inhibition of pro-inflammatory cytokines via suppression of the JNK/c-Jun signaling axis and suggests that A. clathratum could serve as a marine-derived anti-inflammatory agent in periodontitis.
Purpose: The purpose of this study is to determine how the incidence of oral cancer has changed over the past few years. Material and Method: In this study, the number of total cancers and lip-oral-pharyngeal cancers by year was compared using public big data from the National Cancer Center. The incidence rate of lip-oral cavity-pharyngeal cancer from 2000 to 2015 was analyzed. Results: In 2000, there were 101,772 cases of all cancers in all men and women. In 2015, there were 202,266 cancer cases in both men and women. In 2000, there were 2,183 cases of lip-oral-pharyngeal cancers for both men and women. In 2015, lip-oral-pharyngeal cancer were 3337 in both men and women. Conclusions: It is possible that oral cancer also increased along with the increase in total cancer, and it is thought that we should focus on preventing cancer in the future.
Adenoid cystic carcinoma(ACC) is an uncommon tumor of the head and neck. It is one of the most common malignant tumor of the salivary glands. Although ACC has clear pathologic features, it can be diagnosed as a benign lesion in terms of cytological and radiologic aspects. In this paper, we report a rare case of ACCACC on tongue that is diagnosed as ACC but appears as a benign lesion in cytological and radiologic views.
The oral cavity is rich in blood flow, which can cause excessive bleeding. Excessive bleeding in oral cavity is rare, but if the cause of the bleeding is not found, the patient's life may be at risk. Therefore, in the case of excessive bleeding, the dentist should consider the cause and provide appropriate first treatment. Hydrofluoric acid is widely used as a material for pre-treatment of ceramics before oral restoration for prosthetics and conservative dentistry. Since hydrofluoric acid is very reactive, when it comes into contact with tissues, even very diluted 0.1% hydrofluoric acid can cause very painful 2-3 degree burns, which heal very slowly. Negative reactions and even deaths of hydrofluoric acid have been reported in other fields, but there are very few case reports of complications related to hydrofluoric acid in the dental field. In this article, we report a case of excessive gingival bleeding after restorative treatment and discuss the effects of hydrofluoric acid on oral soft tissues and blood vessels and its prevention
Non-keratinizing squamous cell carcinoma (NKSCC) is a rare malignancy of the nose and paranasal sinuses which is characterized by a unique anastomosing ribbon-like growth pattern with absent of limited maturation and keratinization. NKSCC accounts for 10-27% of sinonasal squamous cell carcinomas and some of the NKSCCs are reported to be associated with high risk-HPV infection. Advanced lesion can involve the oral cavity with oral symptoms of palatal bulging, surface ulceration mimicking salivary gland tumors. Herein, we report a case of NKSCC of a 46-year old male, which clinically presented as a bulging mass on the mid palate and mimicked a palatal salivary gland tumor. We reviewed the clinical and histopathological considerations required for differential diagnosis of sinonasal carcinoma involving the oral cavity.
Multiple endocrine neoplasia type 2B (MEN2B), which is an autosomal dominant hamartoneoplastic syndrome, is a genetic syndrome. Patients with this syndrome are characterized by multiple mucosal neuromas on the tongue, lips, eyelid margins, and conjunctiva with marfanoid habitus, thick and protruding lips, open bite, and maxillary central diastema. Multiple oral mucosal neuromas are known to appear before the development of medullary thyroid carcinoma (MTC) or pheochromocytoma. Therefore, understanding the oral symptoms is very important for the early diagnosis of this syndrome. We report multiple submucosal neuromas in a 19-year-old male patient diagnosed with MEN2B and review this syndrome.
Orthokeratienized odontogenic cyst (OOC) is a comparatively unusual developmental odontogenic cyst arising from odontogenic epithelium. Recurrence has rarely been noted, and has been reported in less than 2% of cases. Epidermoid cyst (EDC) is a benign cystic lesion, which is lined by stratified squamous epithelium and includes keratin debris. They can present anywhere in the body but are rare in the head and neck areas. In this report, we present an uncommon case of simultaneous occurrence of OOC in mandible and EDC around the areas of both ears in a patient who has no history of genetic syndrome.