간행물
대한구강악안면병리학회지 KCI 등재 The Korean Journal of Oral and Maxillofacial Pathology
- 발행기관 대한구강악안면병리학회
- 자료유형 학술지
- 간기 격월간
- ISSN 1225-1577 (Print)2384-0900 (Online)
- 수록기간 1977 ~ 2024
- 주제분류 의약학 > 치의학 의약학 분류의 다른 간행물
- 십진분류KDC 515DDC 610
권호리스트/논문검색
제30권 제4호 (2006년 8월) 8건
1.
2006.08
구독 인증기관 무료, 개인회원 유료
It is well known that the imbalance between epithelial cell growth and inhibitor factors may cause human epithelial cancer. Over-expression of the epidermal growth factor receptor(EGFR) has been implicated in the development of oral squamous cell carcinoma. ZD1839 inhibits selectively the EGFR tyrosine kinase activity and is clinically used for cancer patients. However the mechanisms by which it exerts its anti-tumor activity remains unclear. This study attempted to determine the mechanisms underlying the effects of ZD1839 on the cellular level and to characterize the effects of ZD1839 with regard to human oral squamous cell carcinoma(OSCC) cell growth. The YD-10B and YD-38 cell lines established from OSCC in the department of Oral Pathology, Yonsei University College of Dentistry and ZD1839(Iressa) were used for this study. The inhibition of cell proliferation induced by ZD1839 was reversible and the lowest dose of ZD1839 that produced statistically significant growth inhibition in YD cell lines were 0.1 μM. The delay in cell cycle progression was induced by 0.1 μM of ZD1839 treatment after 24 hr. This reduction in cell proliferation and cell cycle delay were associated with up-regulation of the cyclin dependent kinase inhibitor(CDKI), P21CIP1/WAF1 and P27KIP1. Reduced expression of cyclin D1 was also observed after treatment with ZD 1839 to YD-38 cells but not to YD-38. The present results suggest that the antiproliferative effects of ZD1839, in vitro was associated with degradation of cyclin D1, which may be used as a possible indicator of a high cell sensitivity to ZD1839.
4,000원
2.
2006.08
구독 인증기관 무료, 개인회원 유료
System L amino acid transporter is a major route for providing living cells with neutral amino acids including several essential amino acids. To elucidate the expression pattern of L-type amino acid transporter 1 (LAT1) in the bone formation process, the expressions of LAT1 and its subunit 4F2 heavy chain (4F2hc) were investigated in the healing process after the implantation of bone graft materials in the calvarial osseous defected rats. Circular calvarial defects (1 cm in diameter) were made midparietally. The rats were divided into 4 groups of 1 control group and 3 experimental groups. In the control group, the defect was only covered with soft tissue flap. In the experimental groups, they were filled with human particulate dentin (particulate dentin group), with plaster of Paris (plaster of Paris group) and with the mixture of human particulate dentin and plaster of Paris with ratio of 2 : 1 by weight (mixture group). The rats were sacrificed at the 1, 2, 4 and 8 weeks after operation and the RT-PCR analysis and immunohistochemical analysis were performed. In the RT-PCR analysis, the mRNAs of LAT1 and 4F2hc were strongly detected in all 4 groups. In the immunohistochemical analysis, at 1 week after operation, the LAT1 protein and its subunit 4F2hc protein were mainly expressed in the osteoblasts, osteocytes and interstitial tissues of the around the defect and inner part of newly forming bone in all 4 groups. The expressions of LAT1 and 4F2hc proteins were decreased at 2 and 4 weeks after operation. The LAT1 and 4F2hc proteins were scarcely expressed at 8 weeks after operation in all 4 groups. These results suggest that the LAT1 and its subunit 4F2hc highly expressed at the early stage of new bone formation and may have an important role in providing cells with neutral amino acids including several essential amino acids at that stage.
4,000원
3.
2006.08
구독 인증기관 무료, 개인회원 유료
Adenoid cystic carcinoma(ACC) is one of the most common malignant tumors of minor salivary glands and can also arise in a variety of sites in the head and neck including the major salivary glands, the esophagus, the lacrimal glands. ACC shows slow but relentless growth, so it shows long-term recurrence. The various reports about prognostic factors which influence the recurrence pattern are introduced but the reports about prognostic factors are rare in Korean adenoid cystic carcinoma patients. We examined 40 ACC patients who finally diagnosed at Department of Oral Pathology, Seoul National University Dental Hospital. Clinicopathologic and immunohistochemical features were reviewed and factors correlated with recurrence and survival were analyzed. The 5-year survival rate of T3,T4 stage was 31.2%, while that of the T1,T2 stage was 88.2%, and the difference 5-year survival and T stage was statistically significant. The rate of local recurrence was 20% and the rate of distant metastasis was 27.5%. Mean recurrence time were 4.8 years and 5.2 years. There was no significant difference between age, sex, T stage, TNM stage, histologic type and recurrence. But the high T stage and the solid type recurred more frequently. There was no significant difference between recurrence rate, 5-year survival rate and Ki-67, MVD expression. But the higher expression of Ki-67, MVD show the higher recurrence rate and the lower 5-year survival rate
4,300원
4.
2006.08
구독 인증기관 무료, 개인회원 유료
An extremely rare case of chondromyxoid fibroma of the zygomatic arch in a 65-year-old woman is presented. Block resection and immediate reconstruction were done with calvarial bone with fixed with microplate and screws through the hemicoronal approach. Follow-up studies have shown no tumor recurrence for 7 years. Also, we carried out an immunohistochemical study. The results showed positive S-100 and vimentin staining, while showing only very weak staining for NSE. The Ki-67 staining study showed a PI-index of only 0.67%.
4,000원
5.
2006.08
구독 인증기관 무료, 개인회원 유료
ISPARC (Secreted protein acidic and rich in cysteine) is detected in the bone stroma during wound-healing process. To understand the roles of SPARC in bony wound-healing process, SPARC cDNA were synthesized from rat calvarial osteoblast culture, and SPARC protein was synthesized from the cDNA. To observe the effects of SPARC protein on the differentiation of osteoblasts, bony defect were made on rat tibia, and the distributions of bone matrix related proteins and SPARC were investigated using immunohistochemistry. In the rat osteoblastic culture using untreated plastic surface, Collagen-SPARC treated surface presented higher protein synthesis than untreated surface or only collagen treated surface. SPARC synthesis in the bony defect of rat tibia was augmented by introducing SPARC to the bony defect. SPARC synthesis were increased from the center of the defect compared to the control. SPARC synthesis in cells of the center of the defect was increased and maintained for 14 days. We could conclude that SPARC introduction may affect the early bone matrix formation, including SPARC, and mineralization in bony wound healing process.
4,000원
6.
2006.08
구독 인증기관 무료, 개인회원 유료
This research was designed to investigate changes of growth factors and bone matrix proteins during the bone healing processes using immunohistochemistry and in situ hybridization. Especially this study was focused on the changes of bone matrix and growth factors around the titanium implant. Threaded implants were introduced into the long bone of tibia. Time dependent changes of several bone associated protein and and its mRNAs were observed. Proteins investigated in this study are collagen, osteonectin(ON), osteopontin(OPN), osteocalcin(OC). Expression of the proteins were measured using immunohistochemistry. VEGF and ON were measured using in situ hybridization, and northen blot technique. Bone regeneration were observed as early as the third day of experiment. Matrix proteins and growth factors observed around implant were identical to the proteins observed in the control group. The expression of the ON, OC and VEGF were observed mainly in the osteoblast-like cell on the surface of new bone around the implant and the cells lining the margin of bone defect apart from the implant. The observation may not result from direct osteoconducting activities of titanium but by passive adsorption of extracellular factors which has bone inducing capacities. These passive adsorption results in the immobilization of the growth factors and consequent prolongation of the activities.
4,000원
7.
2006.08
구독 인증기관 무료, 개인회원 유료
Most Authors reported that mouth guard is a part of equipment for body-contact sports players. Mouth guards protect orofacial injuries but have some problems in breathing and speaking. Some authors reported that mouth guards have also improve the muscle strength and sport ability. This experiment was performed to study the change of masseter muscle EMG after wearing of mouth guard. 10 D university male base ball players were participated in this study. After impression taking, mouth guards were constructed and weared. Masseter muscle EMG and nasal ventilation after ten day's adaptation were checked. They were requested clenching with or without mouth guard. EMG and nasal ventilation were checked by iworx 104 instrument simultaneousley. The result showed that masseteric EMG were improved and nasal ventilation were stable after wearing mouth guard. It concluded that mouth guard had improved muscle activity and stabilized the nasal ventilation depend on experimental method.
4,000원
8.
2006.08
구독 인증기관 무료, 개인회원 유료
4,000원
