It is well known that oral pathology is an essential bridge between basic and clinical science in dental field. Although oral pathology has been introduced to Korean dental science since 1945, there is not yet presented about oral pathologic history. The purpose of this study are to summarize and to introduce Korean oral pathologic history in serial form for Korean oral pathologists.

It is well known that oral pathology is an essential bridge between basic and clinical science in dental field. Although oral pathology has been introduced to Korean dental science since 1945, there is not yet presented about oral pathologic history. The purpose of this study are to summarize and to introduce Korean oral pathologic history in serial form for Korean oral pathologists.

It is well known that oral pathology is an essential bridge between basic and clinical science in dental field. Although oral pathology has been introduced to Korean dental science since 1945, there is not yet presented about oral pathologic history. The purpose of this study were to summarize and to introduce Korean oral pathologic history in serial form for Korean oral pathologist.

It is well known that oral pathology is an essential bridge between basic and clinical science in dental field. Although oral pathology has been introduced to Korean dental science since 1945, there is not yet presented about oral pathologic history. The purpose of this study was to summarize and to introduce Korean oral pathologic history in serial form for Korean oral pathologist.

This research was designed to investigate changes of growth factors and bone matrix proteins during the bone healing processes using immunohistochemistry and in situ hybridization. Especially this study was focused on the changes of bone matrix and growth factors around the titanium implant. Threaded implants were introduced into the long bone of tibia. Time dependent changes of several bone associated protein and and its mRNAs were observed. Proteins investigated in this study are collagen, osteonectin(ON), osteopontin(OPN), osteocalcin(OC). Expression of the proteins were measured using immunohistochemistry. VEGF and ON were measured using in situ hybridization, and northen blot technique. Bone regeneration were observed as early as the third day of experiment. Matrix proteins and growth factors observed around implant were identical to the proteins observed in the control group. The expression of the ON, OC and VEGF were observed mainly in the osteoblast-like cell on the surface of new bone around the implant and the cells lining the margin of bone defect apart from the implant. The observation may not result from direct osteoconducting activities of titanium but by passive adsorption of extracellular factors which has bone inducing capacities. These passive adsorption results in the immobilization of the growth factors and consequent prolongation of the activities.

ISPARC (Secreted protein acidic and rich in cysteine) is detected in the bone stroma during wound-healing process. To understand the roles of SPARC in bony wound-healing process, SPARC cDNA were synthesized from rat calvarial osteoblast culture, and SPARC protein was synthesized from the cDNA. To observe the effects of SPARC protein on the differentiation of osteoblasts, bony defect were made on rat tibia, and the distributions of bone matrix related proteins and SPARC were investigated using immunohistochemistry. In the rat osteoblastic culture using untreated plastic surface, Collagen-SPARC treated surface presented higher protein synthesis than untreated surface or only collagen treated surface. SPARC synthesis in the bony defect of rat tibia was augmented by introducing SPARC to the bony defect. SPARC synthesis were increased from the center of the defect compared to the control. SPARC synthesis in cells of the center of the defect was increased and maintained for 14 days. We could conclude that SPARC introduction may affect the early bone matrix formation, including SPARC, and mineralization in bony wound healing process.

Adenoid cystic carcinoma(ACC) is one of the most common malignant tumors of minor salivary glands and can also arise in a variety of sites in the head and neck including the major salivary glands, the esophagus, the lacrimal glands. ACC shows slow but relentless growth, so it shows long-term recurrence. The various reports about prognostic factors which influence the recurrence pattern are introduced but the reports about prognostic factors are rare in Korean adenoid cystic carcinoma patients. We examined 40 ACC patients who finally diagnosed at Department of Oral Pathology, Seoul National University Dental Hospital. Clinicopathologic and immunohistochemical features were reviewed and factors correlated with recurrence and survival were analyzed. The 5-year survival rate of T3,T4 stage was 31.2%, while that of the T1,T2 stage was 88.2%, and the difference 5-year survival and T stage was statistically significant. The rate of local recurrence was 20% and the rate of distant metastasis was 27.5%. Mean recurrence time were 4.8 years and 5.2 years. There was no significant difference between age, sex, T stage, TNM stage, histologic type and recurrence. But the high T stage and the solid type recurred more frequently. There was no significant difference between recurrence rate, 5-year survival rate and Ki-67, MVD expression. But the higher expression of Ki-67, MVD show the higher recurrence rate and the lower 5-year survival rate

ReαlITent aphthous stomatitis (RAS) appears to be one of the most common oral diseases. However, the defmitive etiology of RAS is not well established, though many etiologic faαors have been suggested and examined. The present study was petformed to investigate the association between HIA and Korean recurrent aphthous stomatitis pa디ents. πle proportions of class 1 and class II HIA types expressed in 49 Korean subjects affected by recurrent aphthous stomatitis (RAS) and in 50 healthy controls were deteffi1Í11ed by microlymphocytotoxicity test. 까le sig띠ficance of the data was analyzed by chi-square test and Fisher' s exact test. πle proportions of HIA-Cw1 and -DR9 antigens were significantly higher in RAS pa디ents (p(0.05), whereas those of HIA-DR4 and -DQ2 antigens were significantly lower (p(0.05). 까le odds ratio (OR) were 2.8 for HIA-Cw1 and 2.7 for -DR9. πle etiologic fractions (EF) were 0.262 and 0.193, respectively. The results s맹gest that, in Koreans, there Í$ a sig띠ficant relation between HIA antigens and RAS. Genetic faαors ， reflected in the HIA type, may play an in1portant role in the development of RAS.

Alterations in cell surface receptors and adhesion molecules which regulate cell-cell and cell-matrix interactions have been 뻐plicated in tumor processes. In order to investigate the effect of integrin expression on the invasiveness of oral sqllamous cell carcinoma, integ띠1 expression in the celllines such as SCC-4, SCC-9, SCC-15, and SCC-25 was analyzed, and the comparison between cell adhesion assay towards extracellular matrix proteins and in vitro invasion assay following inhibition of the functional domain of the integrins using blocking antibodies against the specific integrins 낀 nd Arg-Gly-Asp (RGD) peptide were carried out. The expression of integrin a 2, a 3, a 6 was detected in all oral squamous cell carcinoma celllines. In contrast, the expression of a vß6 integrin is detected in SCC-4 and SCC-9, not in SCC-1 5 and SCC-25. 까1e adhesion of SCC-4 cell line to collagen 1, laminin, and fibronectin was significantly reducecl by σeatment with a 3-, a 6-, and a vß6-blocking antibody, respectively (p (0.05). 꺼.1e invasion of SCC-4 cell line throllgh Matrigel was significantly reduced by treatment with v 6-blocking antibody and RGD pepticle (p(0.05). These results sllggested that specifìc integrins play an in1portant role in the process of adhesion and invasion of oral squamous cell carcinoma cells and the expression of a vß6 integrin is believed to the enhance its invasivene잃.