It is well known that oral pathology is an essential bridge between basic and clinical science in dental field. Although oral pathology has been introduced to Korean dental science since 1945, there is not yet presented about oral pathologic history. The purpose of this study are to summarize and to introduce Korean oral pathologic history in serial form for Korean oral pathologists.
The purpose of this study was designed to identify the health care condition aggressively to urban and semi-urban seniors and to inform the importance of prevention prior to treatment for better old age. A total of 200 seniors who were over the age of 65 and lived specific area of Seoul and Daeboo-island Ansan-city, from 7 September to 4 October 2012, and used self-developed questionnaire. The result of relevance analysis for oral health care demands shows that seniors from Ansan-city had higher dental prosthesis demands(the average 4.43) than seniors from Seoul(3.96) and the difference was statistically significant(p<0.01). Analysis of the correlation between items represented positive(+) relation in all items and same age distribution. Dental prosthesis has high correlation in every items, but fluorine treatment has low correlation relatively. Correlation between independent variables and dependent variables was slightly high, R=0.356(35.6%). However daily activity, oral heath care and anxiety times showed statistical significances. The result of this study shows that there are significant differences between urban area and semi-urban area. Therefore, authorities need to offer oral health education.
Smoking is a risk factor for oral leukoplakia and oral cancer, as well as lung cancer, cardiovascular diseases and many other systemic diseases. Smoking is considered increasing factor of some oral diseases involved indigenous bacteria. In addition, a relationship between smoking and infection of Human papillomavirus (HPV), which is associated with oropharyngeal cancer, remains unclear. The aim of this study is to assess whether smoking has an impact on increase of bacteria inducing oral disease such as dental caries and periodontitis, and HPV infection. DNA of saliva gathered from smokers and non-smokers, consisted of men and women, was analyzed using PCR. Oral disease-causing bacteria were more detected in men smokers than men non-smokers and HPV was most found in women non-smokers. Taken together, this study suggests smoking is related with variation of oral microorganism existence in some way.
Chronic inflammation is widely considered to predispose individuals to cancer. Microorganisms facilitate recruitment and activation of inflammatory cells and thus allow release of inflammatory mediators. These molecules can then promote accumulation of mutations, leading to tumor development in the host. Porphyromonas gingivalis, a pathogen causing chronic periodontitis, is detected in oral squamous cell carcinoma (OSCC) tissues. Considering a strong link between chronic inflammation and tumor development, functional consequences of P. gingivalis infection may include malignant transformation of the host cells. In this study, we monitored transcriptional changes induced by invasion of P. gingivalis in OSCC cells using microarrays. Our preliminary results suggest changes in a wide range of genes involved in inflammation, apoptosis and autophagy, tumor progression, and carcinogenesis. Further studies on molecular mechanisms underlying these changes will lay a useful foundation to elucidate the role of microorganism-related inflammation and for the development of preventive and therapeutic agents for oral cancer.
Development of squamous cell carcinoma around dental implants is an uncommon clinical manifestation with only a few cases described in the literature. Recently, we observed primary squamous cell carcinoma that developed from leukoplakia around dental implants. We report this case to emphasize the importance of careful oral examination, for implant surgery has to be preceded by thorough evaluation of oral mucosal conditions.
Clear cell adenocarcinoma (CCA) is a rare malignant neoplasm of salivary gland that represents only 1% of all salivary gland tumors. CCA is histopathologically characterized by monotonous, glycogen-rich, round to ovoid clear cells intermixed with hyalinized stroma. However, other salivary gland tumors such as mucoepidermoid carcinoma, acinic cell adenocarcinoma, oncocytoma, epithelial-myoepithelial carcinoma, and myoepithelial carcinoma should be ruled out to diagnosis CCA. We herein report a case of CCA involving the soft palate in a 56-year-old female. It is essential to consider CCA in the differential diagnoses of clear cell tumors.