간행물
대한구강악안면병리학회지 KCI 등재 The Korean Journal of Oral and Maxillofacial Pathology
- 발행기관 대한구강악안면병리학회
- 자료유형 학술지
- 간기 격월간
- ISSN 1225-1577 (Print)2384-0900 (Online)
- 수록기간 1977 ~ 2025
- 주제분류 의약학 > 치의학 의약학 분류의 다른 간행물
- 십진분류KDC 515DDC 610
권호리스트/논문검색
제49권 제1호 (2025년 2월) 3건
1.
2025.02
구독 인증기관 무료, 개인회원 유료
Oral Lichen Planus (OLP) is a T-cell-mediated autoimmune disease, with the reticular type being the most common among its subtypes, while the erosive type is known to have a relatively higher risk of malignant transformation. The reticular subtype of OLP has a low risk of malignancy, whereas the erosive subtype has a higher risk, leading to a debate on whether OLP should be considered a precancerous lesion. On the other hand, Oral Squamous Cell Carcinoma (OSCC) is the most common malignant tumor occurring in the oral cavity. It often originates from precancerous lesions, and due to its often unclear early symptoms, there is a growing need for early diagnosis. This study aims to identify salivary biomarkers associated with malignant transformation from OLP to OSCC through a literature review. The review was conducted using the PubMed and Google Scholar databases, focusing on the last 20 years. The search keywords used were "Oral lichen planus reticular," "Oral lichen planus erosive," "Oral squamous cell carcinoma," and "Biomarker." Compared to healthy controls, a total of 48 biomarkers showed increased or decreased expression in OLP-reticular, 43 in OLP-erosive, and 54 in OSCC. There were 27 common biomarkers between OLP-reticular and OLP-erosive, and 11 common biomarkers between OLP-erosive and OSCC. Nine biomarkers were common across OLP-reticular, OLP-erosive, and OSCC. Among the 27 biomarkers showing a shift from OLP-reticular to OLP-erosive, TNF-α, IL-1β, IL-6, IL-8, and TBARS were observed to increase in expression as the condition progressed from OLP-reticular to OLP-erosive. The nine biomarkers involved in the transition from OLP-reticular to OLP-erosive and subsequently to OSCC were TNF-α, IL-1α, IL-1β, IL-6, IL-8, CD44, MMP-9, Catalase, and Survivin. Notably, Survivin was found to decrease in expression in both OLP-reticular and OLP-erosive compared to healthy controls, but its expression increased in OSCC, making it the most noteworthy biomarker.
4,900원
2.
2025.02
구독 인증기관 무료, 개인회원 유료
Various cystic diseases or benign tumors can occur in the jaw, and diagnosis through accurate analysis is essential. In clinical examination, objective tests such as palpation, percussion, and pulp vitality tests are mainly performed on the patient's subjective symptoms, and differential diagnosis is performed by combining radiological and histopathological examinations. This study aims to analyze the incidence rate, location, and recurrence rate of cystic diseases and benign tumors that appear as radiolucent lesions in the jaw. From 2016 to 2020, 1,293 patients diagnosed with cystic diseases or benign tumors with radiolucent radiographic features in Pusan National University Hospital were identified. Under general anesthesia, patients were subjected to cyst enucleation or excision, and the masses were sent for pathohistological examination at the Department of Pathology, Pusan National University Hospital for definitive diagnosis. The incidence rate, location, and recurrence rate of the diseases mentioned above were analyzed. 1,293 patients were diagnosed, with dentigerous cysts being the most common, followed by radicular cysts, odontogenic keratocysts (OKC), and ameloblastomas. Most ameloblastomas, dentigerous cysts, and OKCs were located in the mandibular posterior region, whereas radicular cysts were predominantly observed in the maxillary anterior region. Recurrence was most notable in ameloblastomas and OKCs. Dentigerous cysts are the most common radiolucent jaw lesions, while ameloblastomas and OKCs show high recurrence rates, thus requiring careful management. The lesions vary in their predominant locations, with ameloblastomas, dentigerous cysts, and OKCs commonly occurring in the mandibular posterior region, and radicular cysts in the maxillary anterior region. Given the differences in recurrence rates and site predilections, it is crucial to differentiate these lesions accurately based on their characteristics and provide appropriate treatment tailored to each type.
4,000원
3.
2025.02
구독 인증기관 무료, 개인회원 유료
Skin color is primarily determined by the amount of melanin pigmentation in the skin. In recent years, cosmetic compositions have been developed to reduce the melanin pigmentation in the skin. Treatment of the skin with whitening agents, from the pharmacological and cosmetological views, should provide safety and efficacy without side effects. Currently used whitening agents which are mostly cause many harmful and cytotoxic effects. In view of the lack of safe whitening agents, this study has been conducted to find the stable and harmless compounds inhibiting melanogenesis. The use of light and Herbal extract for the purpose of skin whitening has been formally reported. So, this study is to investigate the effects of LED irradiation and Bletillae rhizoma (Br) extract on tyrosinase activity and melanin biosynthesis in B16F0 melanoma cells. Melanin biosynthesis was induced by α-MSH. Experimental group were conducted five groups; 1) Pre-LED group (LED light irradiation, followed by 1 μM α-MSH) 2) Post-LED group (α-MSH treat, followed by LED light irradiation) 3) Pre-Br extract group (Br extract treat, followed by 1 μM α-MSH) 4) Post-Br extract group (α-MSH treat, followed by 10 μg/ml Br extract) 5) LED and Br extract group. The melanin contents, tyrosinase activity, dendrite length of cells and expression of melanogenesis-related genes under LED light irradiation and Br extract treatment were investigated. Pre-635, Post-425 nm and Post-Br extract group were significantly reduced melanin contents and tyrosinase activity compared with other group. But both for LED irradiation and Br extract group, melanin contents and tyrosinase activity were increased. However, Pre-425 nm and Post-Br extract group could reduce the melanin contents, tyrosinase activity and dendrites length of cells. In addition, the expression of melanogenesis-related proteins, including microphthalmia associated transcription factor (MITF) and tyrosinase (TYR) is inhibited. The Pre-425 nm and Post-Br extract group activated Extracellular signal-regulated kinase (ERK) phosphorylation and involved in the inhibition of melanogenesis via stimulation of MITF degradation. These results indicate that the inhibitory effect of Pre-425nm irradiation and Post-Br extract on melanogenesis are derived from reduced TYR expression via the downregulation of MITF signaling, as well as acceleration of ERK phosphorylation. Thus, these results suggest that Pre-425nm irradiation and Post-Br extract could prevent and treat melanin hyperpigmentation or useful in whitening agents.
4,300원
