Langerhans cell histiocytosis (LCH) is a rare disease that arises from an abnormal increase in histiocytes. Due to its rare occurrence, the diagnosis of LCH is often delayed or missed. This report presents a case of LCH in a 16-month-old girl. After biopsy, the patient’s previous medical records were obtained. The records described the presence of a yellowish plaque on the forehead since birth, a characteristic feature of LCH. Earlier knowledge of this medical history would have helped facilitate the diagnosis of LCH. This report aims to inform clinicians of the clinical and histopathological features of LCH in order to aid in the early diagnosis of this disease, which can occur in infancy.
Synovial cysts of the temporomandibular joint are rare. They commonly occur in the wrist, knee and feet. The main symptoms of synovial cysts occurring in the temporomandibular joint include preauricular pain and swelling, and surgical removal is the gold-standard treatment. A 54-year-old woman who presented with swelling of the right temporomandibular joint visited Kyungpook National University Dental Hospital. She had undergone enhanced computed tomography from another hospital, which showed a 1.1 × 0.8 × 1 cm well-defined rounded cystic lesion on the lateral area of the right temporomandibular joint. A synovial or ganglion cyst was suspected. The cystic lesion was surgically removed under general anesthesia and was histopathologically diagnosed as a synovial cyst. Histopathological findings show a lumen surrounded by loose fibrous tissue, and the lining is in a folded form and is composed of synovial cells.
Orthokeratienized odontogenic cyst (OOC) is a comparatively unusual developmental odontogenic cyst arising from odontogenic epithelium. Recurrence has rarely been noted, and has been reported in less than 2% of cases. Epidermoid cyst (EDC) is a benign cystic lesion, which is lined by stratified squamous epithelium and includes keratin debris. They can present anywhere in the body but are rare in the head and neck areas. In this report, we present an uncommon case of simultaneous occurrence of OOC in mandible and EDC around the areas of both ears in a patient who has no history of genetic syndrome.
Multiple endocrine neoplasia type 2B (MEN2B), which is an autosomal dominant hamartoneoplastic syndrome, is a genetic syndrome. Patients with this syndrome are characterized by multiple mucosal neuromas on the tongue, lips, eyelid margins, and conjunctiva with marfanoid habitus, thick and protruding lips, open bite, and maxillary central diastema. Multiple oral mucosal neuromas are known to appear before the development of medullary thyroid carcinoma (MTC) or pheochromocytoma. Therefore, understanding the oral symptoms is very important for the early diagnosis of this syndrome. We report multiple submucosal neuromas in a 19-year-old male patient diagnosed with MEN2B and review this syndrome.
Dentigerous cyst is considered one of the representative cystic lesions, which accounts for approximately 15%-30% of the odontogenic cysts. Although its recurrence rate is low, a small proportion of dentigerous cysts converted into ameloblastomas, squamous cell carcinomas, and mucoepidermoid carcinomas. Here we present an uncommon case characterized by histopathological transformation from a dentigerous cyst to an ameloblastoma, and further investigate the factors contributing to its conversion.
With few reported cases, cystic hygroma is known to occur mainly in patients under the age of two years. Cystic hygroma can eventuate in any area; however, it mostly occurs in the cervicofacial area. If cystic hygroma occurs in this area, then the lesion may be related to the vital structures. Therefore, a complete surgical resection may be impossible and difficult to perform. This incident affects the high recurrence rate of cystic hygroma. The purpose of this report is to present a case of cystic hygroma occurring on the left side of the neck of a 47-year-old male patient as well as a review of literatures.
The long-tailed goral (Naemorhedus caudatus) is an endangered animal species in all its habitats worldwide, including South Korea. The imbalanced sex ratio in fragmented habitats is closely associated with extinction. Therefore, sex identification using wild animal samples would be necessary. However, only a few studies have been reported about the sex identification of gorals. In this study, we thus aimed at comparing the efficiency of sex identification using various goral sample types as templates and the amelogenin (AMEL) and DEAD-box polypeptide 3 (DDX3) genes as target sequences. We extracted DNA from goral feces, tissues, and blood samples, then amplified the AMEL (SE47/SE48 and SE47/SE53 primer pairs) and DDX3 genes for sex identification, comparing the goral DDX3X and DDX3Y target sequences to those in cattle. Our results indicated that the tissue- and blood sample-derived AMEL amplicons showed an unspecific band pattern containing the sex-specific band in the case of both primer pairs we used, whereas the DDX3 amplicon showed only the sex-specific band. In the case of the feces samples, only the sex-specific band was amplified using both the AMEL and DDX3 primer pairs. However, we found that the DDX3 amplicon exhibited a clearer band pattern than the AMEL amplicon. Then, we compared the DDX3X and DDX3Y target sequences between cattle and gorals. We found 5 and 8 nucleotide differences in the DDX3X and DDX3Y sequences, respectively. In conclusion, the DDX3 gene-related sex identification of the long-tailed goral appears to be more efficient and precise than the AMEL gene-related approach. This method could be used for the sex identification of the members of the Bovidae family.
Verruciform xanthoma (VX) is a rare benign lesion of oral mucosa. It has an unclear etiology, and it mainly occurs in the oral cavity; however, it can be found in other locations as well. Oral VX is often clinically confused with papilloma, leukoplakia, condyloma, verruca vulgaris, verrucous carcinoma, or squamous cell carcinoma; therefore, biopsy is required to accurately diagnose this lesion. Our study reports four cases of oral VX with different clinical features but similar histopathological characteristics to emphasize the importance of differential diagnosis.
Ameloblastoma is an odontogenic tumor characterized by various sites of metastasis, malignant transformation, and a high recurrence rate over time. Ameloblastic carcinoma(AC) is the term reserved for an ameloblastoma with histologic evidence of malignancy in the primary tumor. AC is classified into two types: most ACs occur de novo, and only few cases of malignant transformation of ameloblastoma become apparent. Here, we report a case of AC, arising from recurrent acanthomatous ameloblastoma on the maxillary sinus, in a 60-year-old male patient. The mass was first diagnosed as acanthomatous ameloblastoma; subsequently, surgical curettage was performed thrice while partial maxillectomy was performed twice. On the fifth recurrence, the tumor was identified as AC.
Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease, KFD) is a benign self-limiting lesion that can self-heal when no severe symptoms are present. KFD resembles tuberculous lymphadenitis and malignant lymphoma. Thus, early differential diagnosis will minimize unnecessary evaluation and treatment. Histological examination of a lymph node biopsy or fine needle aspiration could be a reliable method for KFD diagnosis. This study reports a case of histiocytic necrotizing lymphadenitis of the right cervical lymph node in a 52-year-old female patient. According to the fine needle aspiration biopsy result, the patient was diagnosed with Kikuchi-Fujimoto disease and treated with prednisolone (15 mg/day). After treatment, there was no recurrence or adverse event.
절화 장미 스마트팜과 관행농가의 시설현황과 2018년 11월 부터 2019년 1월까지의 재배환경 및 절화 품질을 비교하였다. 두 농가 모두 연동 플라스틱 온실이었고, 스마트팜은 자동제어시스템이 설치되어 있었으나, 일부만 제어가 되고 있었다. 농가의 재배환경을 분석한 결과, 스마트팜의 시설 내 온도는 계절에 관계없이 일정하게 유지되고 있었으나 광량과 습도는 두 농가 모두 적정 값에 미치지 못하는 것으로 나타났다. 재배 품종의 절화 특성을 조사하여 품질을 분석한 결과, 스마트 팜의 ‘Soprano’ 품종은 11월부터 1월까지 절화수명이 약 8.6~ 9.8일로 유사하게 나타났으며 ‘Victoria’ 품종은 1월에 통계적으로 유의차 있게 다소 수명이 단축되었으나 1월을 제외하고는 약 8.2~8.6일로 수명이 비슷한 것으로 조사되었다. 관행농가의 ‘3D’와 ‘Kensington Garden’ 품종은 절화수명이 일정하게 나타나지 않았다. 절화수명에서 품종별 유의적 차이는 없었고 월별 유의적 차이만 나타났는데 이는 품질 차이가 아닌 온실 환경 때문이라고 판단된다. 스마트팜은 CCTV나 어플리케이션을 통해 실시간으로 온실관리를 할 수 있어 재배환경이 다소 일정하게 유지되었으며, 추후 ICT(Information and Communications Technologies) 기술 확대로 완전자동제어시스템이 이루어져 균일한 품질의 절화 장미가 생산될 수 있도록 해야 될 것으로 판단된다.
Pleomorphic adenoma (PA) is the most common benign salivary gland tumor. Being pleomorphic, its histologic characteristics can be considerably varied, showing epithelial (ductal and non-ductal) cells and mesenchyme-like tissues (chondroid, myxoid, and osseous). Here, we present a rare case of a 76-year-old female presenting with a 2.0 cm PA with an epidermoid cyst of minor salivary glands on the soft palate.
In the case of foot-and-mouth disease (FMD), there is a great deal of impact on the national economy due to the disposal of diseases, the cost of disease control such as vaccination, reduction of productivity, and restriction of international trade of livestock products. Therefore, appropriate diagnostic methods for sensitive, accurate and rapid identification of virus serotypes are continuously required in terms of early prevention of FMD. This study was conducted to confirm the feasibility of immuno-PCR diagnostic method for the more sensitive detection of Korean FMD virus (FMDV). We synthesized a partial FMD type A viral gene. Protein antigen, monoclonal and polyclonal antibodies of FMDV were cloned, expressed and purified and then magnetic particles were attached to polyclonal antibodies and and oligomers to monoclonal antibodies for the immnuno-PCR. We confirmed the antigen-antibody and oligomer reaction using ELISA, Western blot, and real-time PCR. These results show that Korean FMDV can be detected by using difference of Ct values between positive group and negative group using immuno-PCR.. The results of this study also suggest that this technique will be the basis of the diagnosis method to detect Korean FMDV more sensitively in the future.
Pseudosarcomatous fibromatosis (PSF), also known as nodular fasciitis and pseudosarcomatous fasciitis, is a rare, benign proliferation of fibroblasts and myofibroblasts. It is often misdiagnosed as sarcoma because of its characteristic rapid progression, leading to unnecessary and aggressive surgery. Here we report a case of PSF found in the masseter muscle in a 26-year-old female. The mass that could be misdiagnosed because of its rapid growth characteristics was surgically excised by an intraoral approach and diagnosed as PSF by histopathologic examinations.
본 연구의 목적은 지역아동센터의 원예활동 프로그램 인식과 운영현황을 조사하여 향후 지역아동센터 원예활동 프로그램 발전을 위한 기초자료를 제공하는 것이다. 이를 위하여 충청남도 천안시에 위치한 지역아동센터 소장을 대상으로 2018년 2월 26일부터 2018년 3월 9일까지 방문, 이메일, 전화를 이용하여 설문조사를 실시하였다. 설문을 통해 수집된 자료는 SPSS 23.0 통계 프로그램을 사용하여 빈도분석, 다중응답분석을 실시하였다. 설문조사를 한 결과, 천안시의 지역아동센터 중 원예활동 프로그램을 실행해 본적이 있는 곳은 49%, 실행해보지 않은 곳은 51%로 나타났다. 실행해 본 적이 있는 곳 중 3개월 이상 프로그램을 진행한 센터는 40%에 불과했으며 주 1회, 1시간으로 복지원예사가 진행하였다. 지역아동센터에서 원예활동 프로그램을 시행하지 않은 가장 큰 이유는 ‘예산’이었다. 인지도를 살펴보면, 응답자 중 96.1%가 원예활동 프로그램이 필요하다고 생각하였으며 56.9%가 원예활동프로그램에 매우 관심이 있다고 답하였다. 원예활동 프로그램의 실행으로 지역아동센터가 아동에게 기대하는 효과로는, 정서안정과 사회성 발달에 도움이 될 것이라는 의견이 높게 나타났다. 위의 결과를 종합하여 보았을 때, 많은 소장이 원예활동 프로그램에 관심은 많지만, 일회성 프로그램으로 인식한다고 생각되어 원예활동 프로그램에 대한 정확한 이해와 교육이 필요하다고 사료되며, 앞으로 지역아동센터에서 프로그램을 진행할 때 ‘정서적 안정’과 ‘사회성 향상’을 목적으로 ‘주 1회’로 지속적인 운영을 할 수 있도록 지역아동센터의 예산확보와 원예활동에 대한 적극적인 홍보가 필요하다고 판단된다.