Single PPM Quality Innovation Program is to pursuit of defects below 10ppm in outgoing quality for strengthen the small and medium enterprise's competitiveness. This study aims to find that whether quality innovation promotion is significant or not in the ISO 9001 certification enterprises. To perform this research, we surveyed CEOs, managers and workers working for manufacturing business, we distributed 250 sheets totally and withdrew 171 sheets. We analyzed 135 sheets that we could use for this research using SPSS 15.0 and AMOS 18.0 program.