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Iron Chelator Differentially Activates Macrophage Inflammatory Protein-3α /CCL20 in Immortalized and Malignant Human Oral Keratinocytes KCI 등재

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대한구강악안면병리학회지 (The Korean Journal of Oral and Maxillofacial Pathology)
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

Macrophage inflammatory prote in -3α (M1P-3a 01' CCL20) is an intr땅uing molecule in CanCel‘ irrununotherapy‘ but M1P-3 a expr ession and signaling are not well under s tood in oral cancer cell s. We investigated CCL20 expression a nd signal trans duction by treating immortal ized hllman oral keratinocyte (IHO찌 and oral ca ncer (뻐 4) cells with defe roxa llline (DFO) and examined the mRNA express ion 01' CCL20 using RT- PCR and ELI8A. lHOK and HN4 cells treated with DFO sbowed increased mRNA and protein expression 01' CCL20. and the upregulation 01' DFO-induced CCL20 expression was higher in IHOK cells than in HN4 cells 8elective inhibitors of p38 and ERKl/2 abol ished DF'O- induced CCL20 expression in both lHOK and HN12 cells. and p38 and ERKl/2 inhibitors prevented DFO- induceddegradati on 01' 1 -κ B and NF'-K B activation. Activation 01' c-fos and c-jun also occmred fo l lowing DFO treatment in IHOK and HN4 cells Collectively, these results suggest that DFO-indllced M1 P- 3a. which is involved in the MAP kinase‘ c-fos, c-jun, and NF-K B pathways, may be an important mediator of the a ntitumor immune response in oral keratinocytes ancl warrants con sideration as a target molecule for oral cancer t reatment

저자
  • Sun-Kyung Lee(Department of Oral & Maxillofacial Pathology, College of Dentistry, Wonkwang University)
  • Dal-Ho Won(Department of Oral & Maxillofacial Pathology, College of Dentistry, Wonkwang University)
  • Hyun-Ock Pae(Department of Oral & Maxillofacial Pathology, College of Dentistry, Wonkwang University)
  • Hun-Taeg Chung(Department of Oral & Maxillofacial Pathology, College of Dentistry, Wonkwang University)
  • Chang-Duk Jun(Department of Oral & Maxillofacial Pathology, College of Dentistry, Wonkwang University)
  • Suk-Keun Lee(Department of Oral & Maxillofacial Pathology, College of Dentistry, Wonkwang University)
  • Eun-Cheol Kim(Department of Oral & Maxillofacial Pathology, College of Dentistry, Wonkwang University)