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제 일형 세포사 표시 조절 키나제는 p38 MAPK 경로를 통하여 세포사에 관여 KCI 등재

Apoptosis Signal-Regulating Kinase 1 Contributes to Anoikis through p38 MAPK Pathway

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  • URLhttps://db.koreascholar.com/Article/Detail/324603
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대한구강악안면병리학회지 (The Korean Journal of Oral and Maxillofacial Pathology)
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

Disruption of cell - matrix attachment results in a loss of prosurvival signals and culminates in programmed cell death, referred to as anoikis , Apoptosis signal- regulating kinase 1(ASKl)/MKK5 is a ubiquitously expressed enzyme that acti vates c-Jun N-terminal kinase/stress-activated protein kinase JNK/SAPK and p38 pathways by direct site specific Ser/Thr phosphoryl ation of their respective MKKs-MKK4/MKK7 for JNK and MKK3/MKK6 for p38 kinases, The kinase activity of ASKl is stimulated by a variety of death signals, including TNF, Fas ligation, reactive oxygen species, and antineoplastic agents , The aim of this study was to investigate the relative importance of ASKl in anOlkls 1n the present study cells which lost their adhesion showed higher rate of cell death in compared to cells which maintained anchorage. 1nterestingly the res ult showed that suspended cells expressing ASK1 were more susceptible to anoikis than suspended cells having no ASK1 1n addition, cellu lar attachment seems to have significant effect on ASKl activity and p38 MAPK protein rather than serum stimulation

저자
  • 이창식(부산대학교 치의학전문대학원 치의학과 구강병리학 교실) | Chang Sik Lee
  • 우복희(부산대학교 치의학전문대학원 치의학과 구강병리학 교실) | Voki Woo
  • 정진(부산대학교 치의학전문대학원 치의학과 구강미생물학 교실) | Jin Chung
  • 이창훈(부산대학교 의학전문대학원 병리학 교실) | Chang Hoon Lee
  • 박혜련(부산대학교 치의학전문대학원 치의학과 구강병리학 교실) | Hae Ryoun Park Correspondence