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구강편평세포암종에서 케모카인 수용체 CXCR-4의 발현과 임상병리학적 지표와의 상관관계 KCI 등재

CXCR-4 Expression in Oral Squamous Cell Carcinomas and Its Relation to Clinicopathologic Factors and PCNA Index

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  • URLhttps://db.koreascholar.com/Article/Detail/324606
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대한구강악안면병리학회지 (The Korean Journal of Oral and Maxillofacial Pathology)
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

The support mechanisms that are involved in lymph node metastasis of oral squamous cell carcinoma remain largely unknown. Recent studies have demonstrated that tumor cells express chemokine receptors and use chemokines to metastasize to the target organ in many malignancies in humans There are few reports about the correlation between chemokin receptor CXCR-4 expression and clinicopathologic factors in oral squamous cell carcinomas. The object of this study was to evaluate the availabili ty of CXCR-4 expression as prognostic marker through correlation analysis of CXCR-4 expression in oral sq uamous cell carcinoma and its r elation to clinocopathologic factors and PCNA index. 80 we investigated CXCR-4 expression of 74 oral squamous cell carcinomas by immunohistochemistry. 44 out of 74 cases(59. 5%) showed CXCH-4 positive and 30 sampl es(40.5%) showed CXCH-4 negative. CXCH-4 expression showed statistically sig nificant correlation wi th lymph node metastasis(p=0.026) ‘ PCNA index (p=0.003) , survial rate(p=0.0003). From the results , it was suggested CXCR-4 oxpression might be useful a prognostic marker in oral squamous cell carClllomas

저자
  • 김미애(서울대학교 치의학대학원 구강병리학교실) | Mi Ae Kim
  • 윤혜정(서울대학교 치의학대학원 구강병리학교실) | Hye Jung Yoon
  • 이재일(서울대학교 치의학대학원 구강병리학교실) | Jae 11 Lee
  • 홍삼표(서울대학교 치의학대학원 구강병리학교실) | Sam Pyo Hong
  • 홍성두(서울대학교 치의학대학원 구강병리학교실) | Seong Doo Hong Correspondence