This is a case reporL of a ra re mi xed odontogenic tumo r, amelob lastic fibro-odontoma in the poste1'ior of r ight ma nd tlbe A 2-year - olcl ma le pa ti enL was referred to our department ['or large tumorous lesion 011 ri ght mandible Radiograph ic examination s howed la rge radi opaque and rad iolu cent lesion with impacted and unerupted tooth, #44‘ #45 , #46 #85 , AJ'Ler s urgi cal enuclea Li on & cu rettage of t he mass , the tumor was confirmed to ameloblastic fibro-odontoma. lt was composed with c1 enta l orga ns a ncl is la nd of odontogeni c epithelium embedded in a cell - ri ch mesenchymal s troma, AIso‘ we ca rri ed out an immunohi stochemical study. The resul ts s howed positive CK7 staining. and showed weekly positi ve for Bcl - 2‘ Ki - 67 s Laining, while CEA, CK8‘ CKl2, CKl6 showed l1egative, Follow-up studies have shown no tumot recurrence for 2 yea rs ,