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사람 골수간엽줄기세포의 증식과 조골세포 분화에 대한 GW9662의 영향 KCI 등재

Effect of GW9662 on Proliferation and Osteoblastic Differentiation of Bone Marrow Derived Stem Cells

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대한구강악안면병리학회지 (The Korean Journal of Oral and Maxillofacial Pathology)
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

Previous ly we have s hown that fï brob last• growth factor-2 (FGF-2) and dexamethasone (Dex) in combination strongly stimulate both p l 이 i fe rati o n a nd differe nt iation of mesenchymal stem cells (MSCs) into osteoblasts and adipocytes, In the present s tudy we invesL igaLed whether inhibition 01' FGF-2 and Dex-induced adipogenic differentiation of bone marrow derived s Lem cells (BMSCs) by GW9662, an antagoni s t of proxisome proliferators-activated receptol γ (PPARy) which plays a key role in ad ipogenic differentiation , enhances proliferation and osteoblastic differentiation of BMSCs Proliferation 01' BMSCs t reated wi 네 FGF-2 a nd Dex was further increased by GW9662 up to 9,7, 10,6, and 7,2% at 3, 5, and 7 days of cul Lu re , Expansion of BMSCs with FGF-2, Dex and GW9662 followed by osteoblastic different iation showed that osteoblas tic differentiation 01' BMSCs was in creased by 37 % (p=O, 01) compared to those expanded with FGF-2 and Dex, ln contrast , ad i pogenic di fferenti a tion of FGF-2 and Dex-expanded BMSCs was substantially reduced to 14% (p=O, 036) by GW9662, Taken toget her , these resul ts demonstrate that FGF-2 and Dex in combination with GW9662 f ur t her stimu late proliferation 01' BMSCs and those cells expanded with these factors acquire enhanced potentiaIs to be dif ferentiated i n to osteoblas ts

저자
  • 김신윤(경북대학교 의과대학 정형외과학교실) | Shin Yoon Kim
  • 신홍인(경북대학교 치과대학 구강병리학교실) | Hong ln Shin
  • 박의균(경북대학교 치과대학 구강병리학교실) | Eui Kyun ParK Correspondence