This paper analyzed structural behaviors of the staggered truss system, typically used in low seismicity regions, resisting the lateral loads such as wind and seismic load. A comparative study of cost and efficiency was carried out by analysing and designing the 10- and 20-story buildings with various types of truss, including pratt, howe, warren, K-, and vierendeel, which may typically be used in staggered truss system. In design, column and truss members are selected in group, and the efficiency of the member design was judged by average demand capacity ratio of the all members in same group. And economic analysis of the system was investigated by the quantity of the structural members. As a result, staggered truss system with the pratt truss and warren truss showed the most economical and efficient performance for 10-story building, and 20-story building, respectively.