Disinfectant/oxidation process is a crucial process in water treatment for supplying safe drinking water. Chlorination is still widely used for water treatment area due to its effectiveness on microbial inactivation and economic feasibility. Recently, disinfection concern in marine environment is increasing, for example, movement of hazardous marine organism due to ballast water, marine environmental degradation due to power plant cooling water discharge, and increase of the amount of disinfectant in the offshore plant. It is needed to conduct the assessment of disinfectant behavior and the development of disinfectant prediction model in seawater. The appropriate prediction model for disinfectant behavior is not yet provided. The objective of the study is to develop chlorine decay model in seawater. Various model types were applied to develop the seawater chlorine decay model, such as first order decay model, EPA model, and two-phase model. The model simulation indicated that chlorine decay in seawater is influenced by both organic and inorganic matter in seawater. While inorganic matter has a negative correlation with the chlorine decay, organic matter has a positive correlation with the chlorine decay.