Medication, Nutrition, and Diet in Chronic Pancreatitis
만성 췌장염은 심한 췌장 실질의 파괴로 인하여 통증, 외분비 및 내분비 기능 장애가 발생하는 질환이다. 만성 췌장염의 임상 양상은 심하고 지속적이며 잘 조절되지 않는 복통과 흡수장애, 당뇨병을 특징으로 한다. 만성 췌장염은 난치성 복통 외에도 원인, 외분비기능, 내분비기능 모두가 일련의 톱니바퀴처럼 맞물려 있다고 생각해야 한다. 단순하게 복통 만을 조절하려고 하거나 흡수장애 만을 고려한 치료는 또 다른 합병증을 유발 할 수 있다. 반면, 원인, 통증, 외분비기능, 내분비 기능을 모두 고려한 다중 접근은 환자의 증상만이 아 니라 삶의 질을 회복시켜 주고 새로운 삶의 원동력을 제공할 수 있다.
Chronic pancreatitis (CP) is an inflammatory disease of the pancreas characterized by progressive fibrotic destruction of the pancreatic parenchyma and resulting in severe pain with pancreatic exocrine and endocrine insufficiency. The clinical manifestations of CP include abdominal pain as well as exocrine and/or endocrine insufficiency. Most patients with CP have abdominal pain. Physicians usually focus on treating pain in CP as opposed to exocrine insufficiency, despite the fact that malabsorption and maldigestion can result in nutrition deficiency. Nutrition deficiency negatively affect outcome if they are not treated. Most important step for early diagnosis of pancreatic exocrine insufficiency in CP is special attention to nutritional status of patients. Abdominal pain, pancreatic exocrine and endocrine insufficiencies should be managed with multidisciplinary approach to prevent complications and to maintain good quality of life. The mainstay of treatment is abstinence of alcohol and smoking, pain treatment, dietary modifications and pancreatic enzyme replacement.