PURPOSES :This study aims to improve complex modeling of multivariable, nonlinear, and overdispersion data with an artificial neural network that has been a problem in the civil and transport sectors.METHODS :Deep learning, which is a technique employing artificial neural networks, was applied for developing a large bus fuel consumption model as a case study. Estimation characteristics and accuracy were compared with the results of conventional multiple regression modeling.RESULTS :The deep learning model remarkably improved estimation accuracy of regression modeling, from R-sq. 18.76% to 72.22%. In addition, it was very flexible in reflecting large variance and complex relationships between dependent and independent variables.CONCLUSIONS :Deep learning could be a new alternative that solves general problems inherent in conventional statistical methods and it is highly promising in planning and optimizing issues in the civil and transport sectors. Extended applications to other fields, such as pavement management, structure safety, operation of intelligent transport systems, and traffic noise estimation are highly recommended.