Present study aimed to determine the effect of ‘bitter melon’, a popularly used fruit in Bangladesh and several other Asian countries, on high-fat-diet-induced type 2 diabetes. To investigate the effect, ethanol extract from bitter melon (BME) as a dietary supplement with mouse chow was used. BME was found to significantly attenuate the high-fat diet (HFD) -induced body weight and total fat mass. BME also effectively reduced the insulin resistance induced by the HFD. Furthermore, dietary supplementation of BME was highly effective in increasing insulin sensitivity and reducing hepatic fat and obesity. These results indicate that BME could be effective in attenuating type 2 diabetes and could therefore be a preventive measure against type 2 diabetes.

• Nal Ae Yoon(Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University)
• Juyeong Park(Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University)
• Jiyeon Lee(Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University)
• Joo Yeon Jeong(Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University)
• Hyun-Kyu Kim(Nutraceutical Food R&D Center, KolmarBNH Co., Ltd.)
• Hak Sung Lee(Nutraceutical Food R&D Center, KolmarBNH Co., Ltd.)
• In Guk Hwang(Dept. of Agrofood Resources, National Academy of Agricultural Science, Rural Development Administration)
• Gu Seob Roh(Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University)
• Hyun Joon Kim(Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University)
• Gyeong Jae Cho(Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University)
• Wan Sung Choi(Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University)
• Dong Hoon Lee(Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University)
• Sang Soo Kang(Dept. of Anatomy & Convergence Medical Science, College of Medicine, Gyeongsang National University) Corresponding author