Plant-parasitic nematodes causes yield losses of more than $100 million per year in the world. Among them, soybeancyst nematode (Heterodera glycines Ichinohe) causes the greatest yield loss to soybean compared to any other pest worldwide.SCN causes yield reductions by feeding on plant nutrients, retarding root growth and inhibiting Bradyrhizobium japonicum(Kirchner) Buchanan nodulation. The primary methods for controlling SCN include planting resistant cultivars and rotationwith nonhost crop. In order to control SCN, we should be breeding resistant soybean cultivars which has resistant genefor this pest. The research that can minimize the damage of the soybean yield is still insufficient, comprehensive andsystematic research is urgently required. Current researches in our lab are discussed.