ESP, English for specific purposes, is an approach to language teaching that has been found to be effective for students who are strongly motivated in their social lives or towards their future goals. With this in mind, the purpose of this study was to investigate whether or not the use of QR code in cellular phones can be effective in teaching a course for ESP such as Medical Tourism English. For the study, twenty six students participated in a questionnaire survey and an interview. Moreover, four independent tests in total, two tests before using QR codes in class and two tests after using QR codes were taken interchangeably based on a time serial analysis. As a result, positive effects were observed in both test results, questionnaire survey, and interview; and the mean scores of those tests after the QR code activities were higher than in those without the activities. In addition, the questionnaire survey and interview data supported the findings; especially, the QR code activity, which helped to decipher the meaning of the technical medical terms and of the process, which students have not experienced so they were not familiar with. In summary, these findings indicate that QR code activities have positive pedagogical implications for ESP education.