In this study, the inhibitory effect of Paecilomyces tenuipes extract on PSA and angiogenesis-related factor expression levels were investigated in human prostate cancer cells, LNCaP. P. tenuipes extract significantly inhibited PSA expression in a dose-dependent manner. We also investigated the inhibitory effect of P. tenuipes extract on the expression of angiogenesis-related genes including VEGF, MMP-2, MMP-9, TIMP-1, and TIMP-2. P. tenuipes extract significantly down-regulated the expression of MMP-2 and MMP-9 in a dose-dependent manner. On the contrary, P. tenuipes increased the expression of TIMP-1 and TIMP-2. Our findings indicate that P. tenuipes exhibits an inhibitory effect on angiogenesis in human prostate cancer cells.

서 론
 재료 및 방법
  버섯시료 추출 방법
  세포 배양
 분석방법
  RNA isolation
  역전사 반응(Reverse Transcription-Polymerase ChainReaction, RT-PCR)
  PCR정량 분석
  통계처리
 결과 및 고찰
  전립선암세포(LNCaP)에서 눈꽃동충하초 열수 추출물의 PSA mRNA 발현 억제효과
  전립선암세포(LNCaP)에서 눈꽃동충하초 열수 추출물의 혈관신생인자 발현 억제효과
 적 요
 감사의 글
 References

• 최영진(건국대학교 식품생명과학부) | Young-Jin Choi
• 범미기(건국대학교 식품생명과학부) | Meiqi Fan
• 최은주(대구가톨릭대학교 체육교육과) | Eun-Ju Choi
• 김은경(건국대학교 식품생명과학부) | Eun-kyung Kim Corresponding author