In this study, β-1,3/1,6-glucan, lactic acid bacteria, and β-1,3/1,6-glucan+lactic acid bacteria were tested for 10 weeks using an immunodeficient animal model infected with LP-BM5 murine AIDS virus On the immune activity. Cytokines production, plasma immunoglobulin concentration, T cell and B cell proliferation were measured. As a result, the T cell proliferative capacity which was weakened by immunization with LP-BM5 murine AIDS virus increased significantly T cell proliferative capacity compared with the red ginseng control group. B cell proliferative capacity was significantly higher than the infected control group. Increased B cell proliferation was reduced. In the cytokine production, IL-2, IL-12 and IL-15 in the Th1-type cytokine increased the secretion of IL-2, IL-12 and IL-15 compared to the infected control. The proliferative capacity of the treated group was higher than that of the mixed treatment group. TNF-α was significantly decreased compared with the infected control group. The IL-4, IL-6 and IL-10 levels were significantly inhibited in the infected control group and the Th1/Th2 type cytokine expression was regulated by immunohistochemistry. IgE, IgA, and IgG levels were significantly lower in the immunoglobulin secretion assay than in the control. As a result, the immunomodulatory effect of β-1,3/1,6-glucan+lactic acid bacteria was confirmed by mixing with LP-BM5 murine AIDS virus-infected immunodeficient animal model.

• Min-Soo Kim(Microbial Biotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 한국생명공학연구원 미생물기능연구센터) | 김민수
• JoongSu Kim(Microbial Biotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 한국생명공학연구원 미생물기능연구센터) | 김중수
• Min Jung Ryu(Department of Cosmetology science, Nambu University, 남부대학교 향장미용학과) | 류민정
• Ki hong Kim(Jeonnam Institute for Regional Program Evaluation, (재)전남지역사업평가단) | 김기홍
• Kwontack Hwang(Department of Food and Nutrition, Nambu University, 남부대학교 식품영양학과) | 황권택 Corresponding author