Pumpkin has long been used as traditional health materials in oriental medicine, pharmacy, medicine, and food industries in many countries. In this study, the water extract and two active components from tendril of young C. moschata Duch. were investigated on inflammation inhibitory activity. The water extract of young C. moschata Duch. showed high cell viability over 95% and it decreased the production of interlukin 6 (IL-6) and tumor necrosis factor (TNF-α) in the capacity of mouse bone marrow-derived macrophages (BMDM) upon lipopolysaccharide (LPS) stimulation. Also, isolated fraction (B4) suppressed the secretion of IL-6 and TNF-α. Among the domestically cultivated pumpkins, B4 fraction contained in the tendril part of them and it comprised of the order of tendril from Cucurbita pepo var. cylindrica, old of C. moschata Duch., and young of C. moschata Duch. These results suggest that water extracts of C. moschata Duch. and purified active compound, rutin, show anti-inflammation activity by suppression of the secretion of IL-6 and TNF-α. It can be applicable as pharmaceutical materials.

• Ha-Na Jeong(Department of and BK21 Plus Program, Chonnam National University, 전남대학교 식품공학과 및 BK21 Plus 프로그램) | 정하나
• Ju-Hee Choi(Laboratory animal Medicine, College of Veterinary Medicine and BK21 PLUS Project Team, Chonnam National University, 전남대학교 수의학과 실험동물학 교실) | 최주희
• Ha-Nul Lee(Laboratory animal Medicine, College of Veterinary Medicine and BK21 PLUS Project Team, Chonnam National University, 전남대학교 수의학과 실험동물학 교실) | 이하늘
• So-Hyeon Lee(Department of and BK21 Plus Program, Chonnam National University, 전남대학교 식품공학과 및 BK21 Plus 프로그램) | 이소현
• Soon-Chang Cho(NaturePureKorea, 네이처퓨어코리아) | 조순장
• Jong-Hwan Park(Laboratory animal Medicine, College of Veterinary Medicine and BK21 PLUS Project Team, Chonnam National University, 전남대학교 수의학과 실험동물학 교실) | 박종환
• Young-Min Kim(Department of and BK21 Plus Program, Chonnam National University, Bio-energy Research Center, Chonnam National University, 전남대학교 식품공학과 및 BK21 Plus 프로그램, 전남대학교 바이오에너지 중점연구소) | 김영민 Corresponding author