In our previous study, active-single compound (ASC), inhibitor of melanogenesis in B16F10 melanoma cell, was identified from Ganoderma lucidum. Thus, the aim of this study is to analyze the change of the ASC contents in G. lucidum when oriental raisin tree (ORT) was added in cultivation of G. lucidum. In HPLC analysis, significantly increased ASC peak was observed in G. lucidum extract supplemented with 15% (v/v) of ORT. In addition, melanogenesis inhibitory effect of G. lucidum extract supplemented with 15% of ORT significantly increased when compared to G. lucidum extract without ORT supplementation. Furthermore, ORT supplementation increased mycelial growth of G. lucidum in both solid and liquid cultivation. These results suggest that oriental raisin tree is useful as natural ingredient for increasing bioactivity including skin-whitening effect and mycelial growth of G. lucidum.

• Jong-Hyeon Kim(Department of Biomedical Chemistry, Konkuk University, Chungju, Korea)
• Hong-il Kim(Department of Biomedical Chemistry, Konkuk University, Chungju, Korea)
• Ji-Woong Kim(Department of Biomedical Chemistry, Konkuk University, Chungju, Korea)
• O-Chul Kown(Department of Biomedical Chemistry, Konkuk University, Chungju, Korea)
• Chang-Soo Lee(Department of Biomedical Chemistry, Konkuk University, Chungju, Korea)
• Young-Jin Park(Department of Biomedical Chemistry, Konkuk University, Chungju, Korea)