Every yaar approximately 12,000 people die from severe burns and thermal injury. Distinguishing a minor burn from a more serious burn involves determining the degree of damage to the tissues of the body. The major lethal problems are massive fluid losses and microbial infections. Xanthan gum and algin are known as natural polymers. we prepared the official burn ointment which were made by xanthan gum and algin. This burn ointment was covered on the skin wound of artificial burned and their effect of healing were investigated by the evaluation of histological and hematological change as a function of time. The result of rats test showed that burn ointments made from xanthan gum and algin were more effective in formation of the new tissue and reduction of inflammation than the controls. From the results obtained in this study, natural polymer ointment which were prepared from xanthan gum and algin were found to satisfy most of the existing ointment substitute.