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대장균 내독소에 의한 토끼의 혈중 지질 및 Cytokines 변화간의 상관성에 관한 연구 KCI 등재

Relationship Between Changes of Lipids and Cytokines in Escherichia coli Endotoxin - induced Septicemic Rabbits

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한국식품위생안전성학회지 (Journal of Food Hygiene and Safety)
한국식품위생안전성학회 (Korean Society of Food Hygiene and Safety)
초록

To investigate the effects of bacterial endotoxin on lipids and cytokines, and to explain the relationships between their changes, we carried out this study using experimentally Escherichia coli (E. coli) endotoxin-induced septicemic rabbits. The triglyceride and cholesterol concentrations in endotoxin groups were generally high (p$lt;0.01 or 0.05) at all sampling time points (from 3hr to 24 hr), while phospholipid concentrations in endotoxin groups elevated in dose-dependent fashion at 3hr and 6hr after endotoxin injection compared to control group (p$lt;0.05). There were significant negative correlations between lipids changes and cytokines (TNF-α and IL-1β) each other (p$lt;0.05), and endotoxic rabbits having higher triglyceride of cholesterol levels shown relatively better conditions compared with others. As a result, the alterations in the lipid compositions caused by endotoxin may imply an active exhibition of the host defense mechanism rather than the disturbances of lipid metabolism.

저자
  • 이원재
  • 장동석
  • 권헌영
  • 김태운
  • 김재영
  • 최국렬
  • 최석철
  • 황수명