In this study, we used dried ginger ethanol extracts which had been used for alleviation of pain and antipyretics for a long time, and confirmed anti-inflammatory and anti-oxidative activities among various pharmacological actions of dried ginger. The result of antioxidant activity using DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging activity, dried ginger shows concentration-dependent radical scavenging activity and more than 80% radical scavenging activity at concentration of dried ginger above 1 mg/ml. Also, in the mouse experiment in which gluten intolerance was induced by providing gluten meal, the effect of inhibiting weight loss was confirmed comparing administrated gluten group and dried ginger administration group. In addition, IL-4, an allergic cytokine, was measured in the small intestine and serum using ELISA (enzyme-linked immunosorbent assay), the results showed that IL-4 production in the dried ginger administration group was significantly reduced compared with the administered gluten 200 mg/ml group. In case of IL-6 and TNF-α production, which are inflammatory cytokines, decreased in the primary culture cell treated with lipopolysaccharide (LPS) for induction of inflammation after treatment with dried ginger in a dose-dependent manner. As a result, it was confirmed that the dried ginger extract has a high antioxidant activity and has a mitigating effect on the gluten intolerance which is an inflammatory allergic reaction.

Introduction
 Methods
  Samples and experimental animals
  Reagents
  Anti-oxidant test by measuring DPPH radical scavenging activity
  Changes in the number of intestinal bacteria
  Measurement of working memory using a Y-maze
   Analysis of spontaneous alternation behaviors
   Development of the entropy and analysis of behaviors using an algorithm
  Measurement of allergic cytokine (IL-4)
  Measurement of inflammatory cytokines (IL-6, TNF-α)
  Measurement of the level of nitric oxide (NO)
  Statistical analysis
 Results and Discussion
  Measurement of DPPH radical scavenging activity
  Changes in weight
  Measurement of working memory using a Y-maze
  Changes in the number of intestinal bac
  Measurement of allergic cytokine (IL-4)
  Measurement of proinflammatory cytokine (TNF-α)
  Measurement of proinflammatory cytokine (IL-6)
  Effects on the suppression of the creation of nitric oxide
 Conclusions
 References

• Shin-Ae Kim(Department of Chemistry, College of Natural Science, Kunsan National University)
• Jin-Woo Kim(Department of Agronomy & Medicinal Plant Resources, Gyeongnam national University of Science and Technology)
• Soo-Cheol Choi(Department of Chemistry, College of Natural Science, Kunsan National University)
• In-Ah Lee(Department of Chemistry, College of Natural Science, Kunsan National University)
• Yong-Wook Shin(Department of Agronomy & Medicinal Plant Resources, Gyeongnam national University of Science and Technology) Corresponding author