In order to reduce the seismic response of the spatial structure, a seismic isolation system with sufficient flexibility is used. The natural period of structure with seismic isolation system got be long to avoid prominent period. In this study, The seismic response of the truss-arch structure, which is modeled in three types according to the rise-span ratio is analyzed on El-centro, Northridge and Artificial Earthquake and compared with the seismic response of the truss-arch structure with lead rubber bearing(LRB). When seismic load is applied to the truss arch with isolation system, the horizontal acceleration response of the truss arch is reduced and vertical seismic response is also reduced. The application of the seismic isolation system is effective in controlling the seismic response.