The purpose of this study is to provide basic data to help ensure the safety and enhance industrial competitiveness of plant construction projects by analyzing the safety management status of, mainly, chemical engineering plant construction projects, and proposing specific measures and models to reduce human/educational, technical/systemic, institutional disasters. This study was done using literature research and case study/empirical study methods. The results of this study are summarized as follows. First, we classified the major disasters from the quarterly released ‘major diaster cases in construction business’from Korea Occupational Safety and Health Agency according to the type of construction and presented the causes and prevention measures.