논문 상세보기

염화벤자코늄과 구연산을 주성분으로 하는 살균 소독제 라미아-킬에 대한 급성경구독성 및 피부자극성 시험에 관한 연구 KCI 등재

Acute Oral Toxicity and Skin Irritation Studies on Lamia-Kill® Composed of Benzalkonium Chloride and Citric Acid

  • 언어KOR
  • URLhttps://db.koreascholar.com/Article/Detail/347385
구독 기관 인증 시 무료 이용이 가능합니다. 4,000원
한국식품위생안전성학회지 (Journal of Food Hygiene and Safety)
한국식품위생안전성학회 (Korean Society of Food Hygiene and Safety)
초록

This test was performed to evaluate the acute oral toxicity and skin irritation of Lamia-Kill®, disinfectant,containing 20% benzalkonium chloride and 10% citric acid. In acute oral toxicity, Lamia-Kill® was orally administered at dose levels of 2,000, 1,000, 500, 250 and 0 mg/kg body weight. After single oral administration to both sexes of SD rats, the rats were observed for 14 days. In primary skin irritation test, New Zealand white rabbits were dermally treated with Lamia-Kill® for 24 hr and observed for 3 days. All rats treated with Lamia-Kill® were induced no toxic signs in mortalities, clinical findings, body weights and gross findings. Also, the disinfectant did not induce any adverse reactions such as erythema and edema on intact skin sites for the most part rabbits, but on abraded skin sites, some rabbits showed very slight erythema on 24 hr after topical application. With the results of this study,Lamia-Kill® have no effect on acute toxicity and side effect in SD rats and was classified as a practically non-irritating material based on the score 0.50 of primary irritation index.

저자
  • 차춘남(경상대학교) | Cha, Chun-Nam
  • 이여은(경상대학교)
  • 손송이(경상대학교)
  • 유창열(경남도립남해대학)
  • 박은기(고신대학교)
  • 최현주(인제대학교) | Choi Hyun Ju
  • 김석(경상대학교) | Suk Kim
  • 이후장(경상대학교) | HuJangLee