Movement and accumulation of cadmium in male Sprague-Dawley rats, fed with brown rice from nearby Janghang smeltery area were investigated. The rat fed with five different cadmium level diets made with Cdpolluted during 12 weeks. The brown rice-polluted with 0.87 ppm Cd (PBR) was sampled from products in the Janghang smeltery area. Diets of brown rice group were brown rice (BR, 0.002 ppm Cd), each 50% of BR and PBR (BR+PBR 50%, 0.44 ppm Cd) and PBR (PBR 100%, 0.87 ppm Cd). To compare with BR+PBR 50%, the another group diet composed the feed (FE, 0.002 Cd ppm) and each 50% of FE and PBR (FE+PBR 50%, 0.44 ppm Cd). Accumulation of Cd, Zn and Cu in blood, liver and kidney rats was measured by GF-AAS. The weight gain in BR groups and FE groups were different 0.22-0.26 and 1.08-1.26 g/day, respectively. Daily intake cadmium was 10.77 and 22.36 μg/rat in BR+PBR 50% and PBR 100%, and 8.83 μg/rat in FE+PBR 50%. Cadmium contents in diets were higher, and total intake of the heavy metals was more increased on the whole. Weights of liver and kidney in FE+PBR 50% group was 2.64 and 2.27 folds higher than those in BR+PBR 50% group. Cadmium contents in blood were increased with intake of BR diet, but Zn and Cu were decreased with them. In the diet groups with the same Cd concentration, Cd content of FE+PBR 50% was higher 1.27 times than that of BR+PBR 50%. In the diet group of BR, BR+PBR 50%, and PBR 100%, the increase of Cd concentration was significantly different to the increase of Cd content in the livers. In the same condition of Cd concentration, Cd contents were higher in the BR+PBR 50% group. In the diet groups of BR, BR+PBR 50%, and PBR 100%, the increase of Cd content in the kidneys led to the increase of Zn and Cu contents. In the same condition of Cd concentration, the diet group with the addition of BR was shown to be 3.11 times higher than with the addition of FE. In view of the results so far achieved, It was closely related with Cd, Zn, and Cu content.

ABSTRACT
 서 론
 재료 및 방법
  식이원의 성분 및 재료
  실험 동물
  흰쥐의 성장 특성
  혈액·혈청 채취 및 장기의 척출
  혈액 중 중금속 분석
  간과 신장 조직 중의 중금속 분석
  통계처리
 결과 및 고찰
  식이 섭취량과 성장 특성
  식이 원 조합에 따른 중금속 섭취량
  간과 신장의 무게
  혈액 중 중금속 농도
  간 조직 중 중금속 농도
  신장 조직 중 중금속 농도
 요 약
 참고문헌

• 김재영(식품의약품안전청 식품의약품안전평가원 식품위해평가부 화학물질과, Food Chemical Residues Division, Department of Food Safety Evaluation, National Institute of Food & Drug Safety Evaluation, Korea Food & Drug Administration) | Jae-Young Kim
• 임효빈(원광대학교 의과대학병원, School of Medicine & Hospital, Wonwang University) | Hyo-Bin Im
• 김성조(원광대학교 식품·환경학과, Department of Food and Environmental Sciences, Wonkwang University) | Seong-Jo Kim
• 백승화(충북도립대학교 바이오식품생명과학과, Department of Biofood Science and Biotechnology, Chungbuk Provincial University) | Seung-Hwa Baek Correspondence to