Pressure-retarded osmosis (PRO) is one of the promising candidates to reduce the reliance on fossil fuels by harnessing energy from the salinity gradient between high-saline and low-saline water. Based on recent advances in the membrane technologies, PRO has re-emerged as a potentially viable energy option. However, several challenges still remain before PRO can reach the commercial stage. Within this context, the objective of this research was to assess the techno-economic feasibility of PRO and PRO-hybrid processes. In particular, model-based performance analysis were conducted for the PRO-hybrid systems. In addition, the influence of colloidal fouling on the performance of PRO process was further investigated. It is expected that this research would help comprehensively understand the PRO-hybrid processes thereby activate further development.