The safety of fake anti-impotence drugs (fake Viagra : 26 samples, fake Cialis : 25 samples) distributed in Gyeonggi province was studied by monitoring the concentrations of anti-impotence pharmaceutical ingredient and their analogues. The concentrations of anti-impotence pharmaceutical ingredient 4 specis and their analogues 17 specis were estimated using by HPLC/PDA, LC-MS/MS. The range of concentration of sildenafil in fake viagra was 40~199 mg/tablet, among them the portion of the concentrations of sildenafil over 150 mg/tablet exceeded 65%. 3 cases in tested samples contained sildenafil and tadalafil. The range of concentration of sildenafil in fake cialis was 102~249 mg/tablet, among them the portion of the concentrations of sildenafil over 150 mg/tablet exceeded 88%. One case in tested samples contained demethylhongdenafil (90 mg/tablet). These results indicate that there were many fake anti-impotence drug contained high level of anti-impotence pharmaceutical ingredients, a sustainable monitoring and the blocked distribution of fake anti-impotence drugs recommended.

ABSTRACT
 재료 및 방법
  재료
  표준품 및 시약
  장비
  실험방법
 결과 및 고찰
  발기부전치료제성분 및 유사물질 확인
  발기부전치료제성분 정량법 검토
  유사비아그라 정량 결과
  유사시알리스 정량 결과
  발기부전치료제 복합성분 검출
  발기부전치료제 유사품 판별
 결 론
 요 약
 참고문헌

• 김범호(경기도보건환경연구원 약품화학팀) | Beom-Ho Kim (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment) Correspondence to
• 전종섭(경기도보건환경연구원 약품화학팀) | Jong-Sup Jeon (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
• 이명진(경기도보건환경연구원 약품화학팀) | Myung-Jin Lee (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
• 박은미(경기도보건환경연구원 약품화학팀) | Eun-Mi Park (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
• 조상훈(경기도보건환경연구원 약품화학팀) | Sang-Hun Cho (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
• 권혜정(경기도보건환경연구원 약품화학팀) | Hye-Jung Kwon (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
• 윤미혜(경기도보건환경연구원 약품화학팀) | Mi-Hye Yoon (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)
• 이정복(경기도보건환경연구원 약품화학팀) | Jong-Bok Lee (Pharmaceutical chemistry Team, Gyeonggi-do Institute of Health and Environment)