The goal of this study is to suggest the conceptual model explaining the mechanism that an asymmetric load elevates low back pain(LBP). The model suggested shows that an asymmetric load in the frontal plane leads to unbalanced hand load, which affects the difference between right and left EMG amplitude on the pairwise back muscles and the increase in muscle fatigue compared with a symmetric load. The model is verified by an experiment that ten male subjects are required to lift and hold at waist height each symmetric and asymmetric load, then the EMG data collected is analyzed concentrating on median frequency used as one muscle fatigue index. The results show that muscle fatigue in lifting an asymmetric load is significantly more than in doing a symmetric load in both low and high load weights. The results means that the movement of load center of gravity(LCG) within a box handled can be one factor elevating LBP, that condition should be controlled by administrative or engineering interventions if possible.