Multiple galvanized steel and aluminium alloy sheets were joined by self-piercing rivet(SPR) and hybrid joining(SPR + adhesive bonding). In this study, tensile-shear load and fatigue properties of multi-layer SPR and hybrid joints were investigated. Moreover, tensile-shear deformation behavior of the joints under different specimen configurations was investigated. Depending on the specimen configurations either top sheet tearing failure mode or rivet tail pull-out failure mode was observed during the tensile-shear tests. The top sheet tearing failure mode resulted in low maximum tensile-shear load, but it led to larger displacement value as compared to that in the tail pull-out failure mode. Maximum tensile-shear load of hybrid joints was about four times higher than that of SPR joints. Also, fatigue limit of hybrid joints was about two times higher than that of SPR joints.