본 연구는 동결 건조한 krill (Euphausia superba) meal을 함량별 섭취시켰을 때 7주령된 Sprague Dawley계 수컷 흰쥐의 혈청 중 alkaline phosphatase (ALP), aminotransferase (AST, ALT) 및 lactate dehydrogenase (LDH) 등 혈청 간 기능 효소활성과 장기 조직의 불소 함량에 미치는 영향을 확인하였다. 기본식이를 급여한 대조군인 CG군을 비롯하여 10%, 20%, 30%의 krill meal을 첨가한 급여군을 각각 KM10군, KM20군, KM30군으로 구분하여 4군의 급여군으로 나누어 5주간 실험 사육한 결과는 다음과 같다.
혈청 중 alkaline phosphatase (ALP), aminotransferase (AST, ALT) 및 lactate dehydrogenase(LDH)의 효소 활성은 대조군인 CG군 보다 krill meal을 함량별 첨가 급여군에서 감소되는 것으로 나타났다. 흰쥐의 혈청 및 장기조직(간, 뇌, 심장, 신장)의 불소 함량은 krill meal의 함량에 따라 불소 함량도 증가되는 것으로 나타났다.
The purpose of this study was to probe the influences of krill (Euphausia superba) meal supplementation on a dose effect relationship between fluoride levels of krill meal and serum hepatic functional enzyme activity such as alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in rats fed experimental diets for 5 weeks. There were no significant differences in the activities of ALP, AST, ALT, and LDH in sera among krill meal diet groups (KM10, KM20, KM30). However, these groups were significantly (p<0.05) lower enzyme activities than control group (CG). The fluoride levels of sera and organ tissues (liver, brain, heart, lung, kidney) in krill meal diet groups (KM10, KM20, KM30) were significantly increased by adding krill meal in comparison with CG. The results indicate that a difficult to found toxicity to the liver from krill meal diet groups.