An imprinted potentiometric sensor was developed for direct and selective determination of gabapentin. Sensor is based on carbon paste electrode adapted by graphene oxide that is decorated with silver nanoparticles and mixed with molecularly imprinted polymers nanoparticles using gabapentin as a template molecule. The synthesized nanoparticles were characterized by Fourier transmission infrared spectroscopy, transmission electron microscopy and X-ray diffraction. Under optimal experimental conditions, the studied sensor exhibited high selectivity and sensitivity with LOD of 4.8×10–11 mol L–1. It provided a wide linearity range from 1×10–10 to 1×10–3 mol L–1and high stability for more than 3 mo. The sensor was effectively used for the determination of gabapentin in pharmaceutical tablets and spiked plasma samples.

Abstract
 1. Introduction
 2. Experimental
  2.1. Instrumentation
  2.2. Reagents
  2.3. Procedure
  2.4. Binding study and entrapment efficiencyof prepared MIP-NPs
  2.5. Sensor selectivity
  2.6. Determination of GP in bulk and pharmaceuticaltablets
  2.7. Determination of GP in spiked humanplasma samples
 3. Results and Discussion
  3.1. Characterization of formed nanoparticles
  3.2. Factors affecting formation of studiedCPE
  3.3. Sensor performance
  3.4. Analytical applications
 4. Conclusions
 References

• Nehad A. Abdallah(Pharmacognosy and Pharmaceutical Chemistry Department, Faculty of Pharmacy, Taibah University, Experiments and Advanced Pharmaceutical Research Unit, Faculty of Pharmacy, Ain Shams University) Corresponding Author
• Heba F. Ibrahim(Experiments and Advanced Pharmaceutical Research Unit, Faculty of Pharmacy, Ain Shams University)