Several bacterial species from the Burkholderia cepacia complex (Bcc) are opportunistic pathogens that lead to infections in patients with underlying lung disease, such as cystic fibrosis, as well as in immunocompromised individuals. Included in the Bcc, Burkholderia contaminans is an emerging pathogen in cystic fibrosis patients. However, this is the first report case of sepsis due to Burkholderia contaminans without cystic fibrosis in child. And we report that successful treatment of sepsis due to Burkholderia contaminans in the child, through antibiotic therapy.