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Single oral dose toxicities of Coccimuel-S composed with diclazuril in mice KCI 등재
- 언어ENG
- URLhttps://db.koreascholar.com/Article/Detail/359605
pp.18-23
This study was carried out to examine the safety of Coccimuel-S, an anticoccidiol, using male and female ICR mice. Mice were orally administered Coccimuel-S at dose levels of 250, 500, 1,000 and 2,000 / body weight for singledose toxicity test. There were no significant differences in change of body weight between control and all groups treated with Coccimuel-S. Also, general toxic symptoms, clinical signs and mortality were not observed. In the hematological analysis, none of the parameters were affected by Coccimuel-S. This suggests that there are no negative effects on homeostasis and immunity. In blood biochemistry analysis, none of the markers were affected by administration of Coccimuel-S. Similarly, there were no significant effects on markers for liver, kidney, skeletal and heart muscle functions in all treated-groups. No remarkable lesions were detected in these organs with macroscopic examination. Since there were no adverse effects of Coccimuel-S in single oral toxicity tests, even at higher doses than normal, it was concluded that Coccimuel-S could be candidates as a safe anticoccidials for the treatment of poultry coccidiosis.
Introduction
Materials and Methods
1. Experimental animals
2. Materials and toxicity test
3. Observation of clinical signs
4. Hematological analysis
5. Blood biochemical analysis
6. Statistics
Results and Discussion
1. Toxic symptoms, clinical signs and mortality rates
2. Change of body weight
3. Macroscopic examinations
4. Hematology
5. Blood biochemistry
References
