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Single oral dose toxicities of Coccimuel-S composed with diclazuril in mice KCI 등재

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예방수의학회지 (Journal of Preventive Veterinary Medicine)
한국예방수의학회(구 한국수의공중보건학회) (The Korean Society of Preventive Veterinary Medicine)
초록

This study was carried out to examine the safety of Coccimuel-S, an anticoccidiol, using male and female ICR mice. Mice were orally administered Coccimuel-S at dose levels of 250, 500, 1,000 and 2,000 / body weight for singledose toxicity test. There were no significant differences in change of body weight between control and all groups treated with Coccimuel-S. Also, general toxic symptoms, clinical signs and mortality were not observed. In the hematological analysis, none of the parameters were affected by Coccimuel-S. This suggests that there are no negative effects on homeostasis and immunity. In blood biochemistry analysis, none of the markers were affected by administration of Coccimuel-S. Similarly, there were no significant effects on markers for liver, kidney, skeletal and heart muscle functions in all treated-groups. No remarkable lesions were detected in these organs with macroscopic examination. Since there were no adverse effects of Coccimuel-S in single oral toxicity tests, even at higher doses than normal, it was concluded that Coccimuel-S could be candidates as a safe anticoccidials for the treatment of poultry coccidiosis.

목차
ABSTRACT
 Introduction
 Materials and Methods
  1. Experimental animals
  2. Materials and toxicity test
  3. Observation of clinical signs
  4. Hematological analysis
  5. Blood biochemical analysis
  6. Statistics
 Results and Discussion
  1. Toxic symptoms, clinical signs and mortality rates
  2. Change of body weight
  3. Macroscopic examinations
  4. Hematology
  5. Blood biochemistry
 References
저자
  • Chun Nam Cha(Engineering Research Institute and Department of Industrial Systems Engineering, Gyeongsang National University)
  • Yeo-Eun Lee(Research Institute of Live Sciences and College of Veterinary Medicine, Gyeongsang National University)
  • In-Jin Kang(Research Institute of Live Sciences and College of Veterinary Medicine, Gyeongsang National University)
  • Chang-Yeul Yoo(Graduate School of Public Health, Gyeongsang National University)
  • Eun-Kee Park(Department of Computer Information, Gyeongnam Provincial Namhae College)
  • Suk Kim(College of Medicine, Kosin University)
  • Hu-Jang Lee(College of Medicine, Kosin University) Correspondence