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Characterization of Biocompatible Lipid-Based Vesicles Contained with Medicinal Herb Extracts KCI 등재
- 언어ENG
- URLhttps://db.koreascholar.com/Article/Detail/359860
pp.853-863
In order to increase the medicinal herbs efficiency of drug delivery, vesicles contained with medicinal herbs were prepared by phosphatidylcholines and surface active agent. Vesicles loaded with medicinal herbs were characterized by UV-spectroscopy, Zetasizer. The antioxidant activity of vesicles was measured by DPPH assay and ABTS radical scavenging assays. Also, an analysis was conducted to determine the effects of anti-inflammatory of vesicles contained medicinal herbs. In addition, the whitening effects of vesicles contained medicinal herbs extract were studied via tyrosinase inhibition assay. The results of vesicles were as follows. Vesicles appeared an average diameter of approximatively 164-599 nm. All studied vesicles contained with medicinal herbs showed antioxidant, anti-inflammatory and whitening effects in a dose-dependent manner. Therefore, this experiment achieves its purpose of synthesizing of vesicles. In conclusion, we recommended that the vesicles loaded with medicinal herbs have ability for anti-aging materials. Specifically, it will apply to cosmetic ingredients.
1. Introduction
2. Materials and Methods
2.1. Preparation of herbal medicine extracts
2.2. Reagent
2.3. Cell culture
2.4. Preparation of medicinal herb vesicles
2.5. Entrapment efficiency of vesicles containedmedicinal herbs
2.6. Characterization of prepared vesicles
2.7. Free radical scavenging activity
2.8. NO assay
2.9. Tyrosinase inhibition assay
2.10. Statistical analysis
3. Results and Discussion
3.1. Characteristics of vesicles containing medicinalherbs
3.2. Measurement of entrapment efficiency
3.3. Analysis of DPPH and ABTS+ radical electrondonating activity
3.4. Measurement of NO production inhibition
3.5. Analysis of whitening effect of vesicles
4. Conclusion
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