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잇꽃씨 추출물의 스코폴라민으로 유발시킨 기억상실 마우스에서 산화적 스트레스와 콜린성 기능 장애 억제를 통한 기억력 개선 효과
Memory Improving Activity of Safflower Seed Extracts against Oxidative Stress and Cholinergic Dysfunction in Scopolamine-induced Amnesic Mice
- 언어ENG
- URLhttps://db.koreascholar.com/Article/Detail/362870
Background : Scopolamine induces cholinergic dysfunction and oxidative stress, and the impairment of memory function. Therefore, oxidative stress and cholinergic dysfunction are important role of the brain pathology of amnesia. In this study, we investigated the impact of Safflower seed against oxidative stress and cholinergic dysfunction on scopolamine-induced amnesic mice.
Methods and Results : Mice were orally pretreated with safflower seed (100 ㎎/㎏ body weight) or vehicle for 7 days, and scopolamine (1 ㎎/㎏ body weight) was injected intraperitoneally, 30 min before the behavior tests such as T-maze and novel objective recognition test on first day. To evaluate learning and memory function, the Morris water maze task was performed for 5 days, consecutively. The results showed that spatial perceptive ability and novel object recognition was significantly increased by preadministration of safflower seed compared with scopolamin-induced control mice in the behavior tests. Consistently, immuno blot revealed the elevated expression of superoxide dismutase 1 in the safflower seed pretreated mice, compared to the control mice. Moreover, protein expression of acetylcholinesterase was decreased in safflower seed pre-treated group.
Conclusion : Subsequently, our results suggests that the Safflower seed extract improved memory impairment through inhibition of cholinergic dysfunction and oxidative stress.
