Quorum sensing (QS) is a cell density-dependent communication mechanism between bacteria through small signaling molecules. When the number of QS signaling molecules reaches a threshold, they are transported back into the cells or recognized by membrane-bound receptors, triggering gene expression which affects various phenotypes including bioluminescence, virulence, adhesion, and biofilm formation. These phenotypes are beneficial for bacterial survival in harsh environments. This review summarizes the application of QS inhibitors for control of biofilm formation and virulence expression of periodontal pathogens.

Quorum sensing
 AI-2-dependent QS in periodontal pathogens
 QS inhibitors for control of biofilm formationof periodontal pathogens
 Conclusions
 References

• Bong-Kyu Choi(Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University) Correspondence to