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Analysis of high-fat diet-induced inflammatory responses in Rhbdf2 knockout mice KCI 등재

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예방수의학회지 (Journal of Preventive Veterinary Medicine)
한국예방수의학회(구 한국수의공중보건학회) (The Korean Society of Preventive Veterinary Medicine)
초록

This study investigated the characteristics of obesity induced by a high-fat diet (HD) over 13 weeks in Rhbdf2 gene knockout (KO) mice. Forty 7-week-old Rhbdf2 wild and KO mice were used and the mice were divided into 4 groups: Wild-ND (n=10, Rhbdf2 wild mice, normal diet (ND)), Wild-HD (n=10, Rhbdf2 wild mice, HD), KO-ND (n=10, Rhbdf2 KO mice, ND) and KO-HD (n=10, Rhbdf2 KO mice, HD). The relative epididymal fat weight in KO-HD was significantly increased compared with that in KO-ND (P<0.01). The relative liver and spleen weights in KO-HD were decreased compared with those in Wild-HD (p < 0.05) and KO-ND (p < 0.01). The mRNA expression of SOD1 in KO-ND was significantly reduced compared with that in Wild-ND (p < 0.05). In Wild-ND and HD, the mRNA expressions of TNF-α and IL-6 in epididymal fat were significantly increased compared with those in KO-ND and HD (p < 0.01). A significant increase of TNF- α and IL-6 mRNA expression was observed in KO-HD compared with KO-ND (p < 0.01). These results indicated that Rhbdf2 genes may regulate high fat diet-induced obesity damage by anti-inflammatory and anti-oxidative roles in fat tissue of mice.

목차
Abstract
 INTRODUCTION
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 REFERENCES
저자
  • Sung-Jun Kim(College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
  • Ki-Hoan Nam(Laboratory Animal Resource Center, Korea Research Institute of Bioscience & Biotechnology)
  • Seul-Gi Park(College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University)
  • Young-Sub Byun(Laboratory Animal Resource Center, Korea Research Institute of Bioscience & Biotechnology)
  • Eun-Kyoung Kim(Laboratory Animal Resource Center, Korea Research Institute of Bioscience & Biotechnology)
  • Sang-Mi Cho(Laboratory Animal Resource Center, Korea Research Institute of Bioscience & Biotechnology)
  • Ha-rim-Kim(Laboratory Animal Resource Center, Korea Research Institute of Bioscience & Biotechnology)
  • Hyoung-Chin Kim(Laboratory Animal Resource Center, Korea Research Institute of Bioscience & Biotechnology)
  • Hu-Jang Lee(College of Veterinary Medicine and Institute of Animal Medicine, Gyeongsang National University) Corresponding Author
  • Beom Jun Lee(College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University) Corresponding Author