Pb2+ and Cr3+ uptake capacity by Sargassum horneri was 185.5㎎ Pb2+/g biomass and 102.6㎎ Cr3-/g biomass, respectively. An adsorption equilibria were reached within about 0.5 hr for Pb2+ and 1 hr for Cr3+. The adsorption parameters for Pb2+ and Cr3+, were determined according to Langmuir and Freundlich model. With an increase in pH values of 2 to 5, Pb2+ uptake was increased, however Cr3+ uptake was constant. The selectivity of mixture solution showed the uptake order of Pb2+>Cu2+>Cr3+>Cd2+. Pb2+ and Cr3+ adsorbed by S. horneri could be recovered from 0.1M HCl, 0.1M HNO3 and 0.1M EDTA by desorption process, and the efficiency of Pb2+ desorption was above 98%, whereas the efficiency of Cr3+ desorption was below 34%.